ALKBH1-mediated tRNA 5-formylcytidine modification facilitates codon-biased translation and leukemogenesis [RNA-seq]
RNA-seq (gene expression) · human · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Topic
- Acute myeloid leukemiaThis series is part of our curated briefing on it.
- Samples
- 12 samples: 3 × MOLM13_shNS_DMSO vs 3 × MOLM13_shNS_Venetoclax vs 3 × MOLM13_shALKBH1_DMSO vs 3 × MOLM13_shALKBH1_VenetoclaxGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- ALKBH1 Drives Tumorigenesis and Drug Resistance via tRNA-decoding Reprogramming and Codon-biased TranslationCancer discovery · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE260905_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1083976 and SRA study SRP493446. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8127842 MOLM13_shNS_DMSO_rep1 MOLM13_shNS_DMSO
- GSM8127843 MOLM13_shNS_DMSO_rep2 MOLM13_shNS_DMSO
- GSM8127844 MOLM13_shNS_DMSO_rep3 MOLM13_shNS_DMSO
- GSM8127845 MOLM13_shNS_Venetoclax_rep1 MOLM13_shNS_Venetoclax
- GSM8127846 MOLM13_shNS_Venetoclax_rep2 MOLM13_shNS_Venetoclax
- GSM8127847 MOLM13_shNS_Venetoclax_rep3 MOLM13_shNS_Venetoclax
- GSM8127848 MOLM13_shALKBH1_DMSO_rep1 MOLM13_shALKBH1_DMSO
- GSM8127849 MOLM13_shALKBH1_DMSO_rep2 MOLM13_shALKBH1_DMSO
- GSM8127850 MOLM13_shALKBH1_DMSO_rep3 MOLM13_shALKBH1_DMSO
- GSM8127851 MOLM13_shALKBH1_Venetoclax_rep1 MOLM13_shALKBH1_Venetoc…
- GSM8127852 MOLM13_shALKBH1_Venetoclax_rep2 MOLM13_shALKBH1_Venetoc…
- GSM8127853 MOLM13_shALKBH1_Venetoclax_rep3 MOLM13_shALKBH1_Venetoc…
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Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.