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Autologous transplantation of P63+ lung progenitor cells in patients with bronchiectasis: a randomized, single-blind, controlled trial

GSE261102 Homo sapiens Expression profiling by high throughput sequencing 7 samples Submitted 2024/10/15 Platform GPL23227
Summary
Non-cystic fibrosis bronchiectasis is a severe respiratory disease characterized by progressive loss of lung function, resulting in high morbidity and even early mortality. Current treatments cannot repair progressive lung damage, which encouraged the exploration of stem and progenitor cell-based regenerative therapies. In current study, we found that the P63+ progenitor cells normally located in airway basal layer could appear in the alveolar spaces of bronchiectasis patients. We successfully cloned and expanded the progenitor cells from the airway brushing tissues of patients. Then we conducted a randomized, single-blind, controlled, phase 1/2 trial to evaluate the safety and efficacy of autologous P63+ progenitor cells transplantation in bronchiectasis patients.
Published in
Autologous transplantation of P63(+) lung progenitor cells in patients with bronchiectasis: A randomized, single-blind, controlled trial
Yan J, Zhang W, Feng Y et al. · Cell reports. Medicine 2024 · PMID 39566467 · doi:10.1016/j.xcrm.2024.101819
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Also filed as BioProject PRJNA1085290 and SRA study SRP493907. Searching any of these in the dataset finder brings you back here.

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