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Transcription factor 21 regulates cardiac myofibroblast formation and fibrosis [scRNA-Seq]

GSE261150 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2024/12/03 Platform GPL24247
Summary
Transcription factor 21 (TCF21) is a basic helix-loop-helix protein required for developmental specification of cardiac fibroblasts from epicardial progenitor cells that normally surround and invade the heart. In the adult heart, TCF21 is expressed in tissue-resident fibroblasts but is downregulated in response to injury or stimuli leading to myofibroblast differentiation. These findings led to the hypothesis that Tcf21 could be a regulator of fibroblast cell fate in the adult mammalian heart and contribute to cardiac fibrosis. Here, single-cell RNA-sequencing was used to study the effect of loss of Tcf21 in cardiac fibroblasts in adult mouse hearts at baseline and after an ischemic cardiac injury (myocardial infarction).
Published in
Transcription Factor 21 Regulates Cardiac Myofibroblast Formation and Fibrosis
Johansen AKZ, Kasam RK, Vagnozzi RJ et al. · Circulation research 2025 · PMID 39629593 · doi:10.1161/CIRCRESAHA.124.325527
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Also filed as BioProject PRJNA1085631 and SRA study SRP494107. Searching any of these in the dataset finder brings you back here.

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