← BioTransfer GEO Dataset Finder
GEO series

Pan-cancer bioinformatics analysis of TNFRSF12A and functional study in colorectal cancer

GSE261177 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/03/13 Platform GPL23227
Summary
Cancer has become a major public health problem in the world, however challenges such as drug resistance, metastasis and cancer recurrence continue to be unresolved issues. Therefore, it is important to find new cancer markers or therapeutic targets. Tn this study, we found TNF receptor superfamily member 12A (TNFRSF12A) upregulated in cancer and associated with a poor prognosis. TNFRSF12A knockdown inhibited growth, colony formation and migration of colorectal cancer cells, and overexpression TNFRSF12A promoted these behaviors of colorectal cancer cells. RNA-seq results showed that TNFRSF12A overexpression caused increased NF-κB signaling, transcriptional misregulation, and significant upregulation of BIRC3 gene, which may be the transcription target of NF-κB member RELA. Through BIRC3 knockdown in overexpressed TNFRSF12A cells, we proved BIRC3 is a key downstream of TNFRSF12A. Therefore, we speculated the existance of TNFRSF12A/RELA/BIRC3 regulatory axis in colorectal cancer.
Published in
The Oncogenic Role of TNFRSF12A in Colorectal Cancer and Pan-Cancer Bioinformatics Analysis
Wang C, Zhao Y, Chen Y et al. · Cancer research and treatment 2025 · PMID 39118523 · doi:10.4143/crt.2024.408
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE261177_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1085698 and SRA study SRP494144. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 6 more — browse all 6 samples with per-sample file links →

Similar datasets

Search all human RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.