Decoding genome-wide DNA binding sites for AR and ERRα in mouse primary hepatocytes
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 10 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 10 samples: 10 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Non-canonical hepatic androgen receptor mediates glucagon sensitivity in female mice through the PGC1α/ERRα/mitochondria axisCell reports · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE261197_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1085739 and SRA study SRP494188. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 10 sample titles: 10 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8137555 WT primary hepatocyte_Veh_ERRα
- GSM8137556 WT primary hepatocyte_Veh_AR
- GSM8137557 WT primary hepatocyte_Veh_input
- GSM8137558 WT primary hepatocyte_GCG_ERRα
- GSM8137559 WT primary hepatocyte_GCG_AR
- GSM8137560 WT primary hepatocyte_GCG_input
- GSM8137561 AR KO primary hepatocyte_Veh_ERRα
- GSM8137562 AR KO primary hepatocyte_Veh_input
- GSM8137563 AR KO primary hepatocyte_GCG_ERRα
- GSM8137564 AR KO primary hepatocyte_GCG_input
- GSE297843 Brg1 defect causes aberrent nucleosome landscape and affects totipotency & pluripotency transcriptional factors binding during embryogenesis [MNase-Seq] 16 samples shares err, binding
- GSE300734 Brg1 defect causes aberrent nucleosome landscape and affects totipotency & pluripotency transcriptional factors binding during embryogenesis [RNA-seq] 25 samples shares err, binding
- GSE302789 Mitochondrial ROS induces metabolic adaptations and maladaptations that differentially regulate ferroptosis sensitivity of the hepatocytes 12 samples shares err, hepatocytes
- GSE285215 Cancer cells avoid ferroptosis induced by immune cells via fatty acid binding proteins 12 samples shares err, binding
- GSE230527 Genome-wide profiling of Kdm2a binding and H3K36me2 of hypoxia-cultured B cells derived from miR-155-sufficient and -deficient mice [ChIP-seq] 18 samples shares genome-wide, binding
- GSE280301 Culturing of primary mouse hepatocytes is associated with major changes to the proteome and transcriptome 12 samples shares hepatocytes, primary
- GSE274374 Benzbromarone exacerbates high-fat-induced lipid accumulation in primary hepatocytes by activating PPARγ [OA] 12 samples shares hepatocytes, primary
- GSE312790 Aberrant mRNA Splicing and Impaired Hippocampal Neurogenesis in Grin2b Mutant Mice 133 samples shares err
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.