Modulation of liver cholesterol homeostasis by choline supplementation during fibrosis resolution
RNA-seq (gene expression) · mouse · 16 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 16 samples: 8 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Modulation of liver cholesterol homeostasis by choline supplementation during fibrosis resolutionHeliyon · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE261310_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1086469 and SRA study SRP494525. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 16 samples.
How we read this: 8 replicated groups read from 16 sample titles; they account for 16 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8140357 WT_1 WT
- GSM8140358 WT_2 WT
- GSM8140359 TAA8w_1 TAA8w
- GSM8140360 TAA8w_2 TAA8w
- GSM8140361 T8_Free1w_con1 T8_Free1w_con
- GSM8140362 T8_Free1w_con2 T8_Free1w_con
- GSM8140363 T8_Free2w_con1 T8_Free2w_con
- GSM8140364 T8_Free2w_con2 T8_Free2w_con
- GSM8140365 T8_Free4w_con1 T8_Free4w_con
- GSM8140366 T8_Free4w_con2 T8_Free4w_con
- GSM8140367 T8_Free1w_choline1 T8_Free1w_choline
- GSM8140368 T8_Free1w_choline2 T8_Free1w_choline
- GSM8140369 T8_Free2w_choline1 T8_Free2w_choline
- GSM8140370 T8_Free2w_choline2 T8_Free2w_choline
- GSM8140371 T8_Free4w_choline1 T8_Free4w_choline
- GSM8140372 T8_Free4w_choline2 T8_Free4w_choline
- GSE228579 Chronic stress disrupts hepatic homeostasis and accelerates liver cancer progression through ADRB2 signaling 66 samples shares homeostasis, liver
- GSE338894 An orally active, gut-enriched AhR agonist demonstrates therapeutic efficacy in colitis through regulation of inflammation, barrier homeostasis, and fibrosis 50 samples shares homeostasis, fibrosis
- GSE310017 Disease-associated mutations on the STAT5B SH2 domain regulate cholesterol and lipid metabolism in liver [RNA-Seq liver] 37 samples shares cholesterol, liver
- GSE328634 Asiatic acid from Centella asiatica alleviates renal fibrosis: coordinated modulation of the gut–kidney axis and retinol metabolism 15 samples shares modulation, fibrosis
- GSE238201 Loss of PPARα function promotes epigenetic dysregulation of lipid homeostasis driving ferroptosis and pyroptosis lipotoxicity in Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD) [RNA-seq] 12 samples shares homeostasis, liver
- GSE256501 Sex differences in Non-Alcoholic Steatohepatitis (NASH) in mice evoked by a fructose-palmitate-cholesterol (FPC)-enriched diet [bulk_liver] 12 samples shares cholesterol, liver
- GSE222707 Cancer-cell-secreted miR-9-5p regulates cholesterol homeostasis to promote tumor metastasis [TF TB Rab27AKD miR-9KO] 12 samples shares cholesterol, homeostasis
- GSE286073 Role of Hepatocyte RIPK1 in Maintaining Liver Homeostasis during Metabolic Challenges [RNA-seq] 10 samples shares homeostasis, liver
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.