GEO series
Ribosome profiling analysis of neuroblastoma cells in response to amidino-rocaglate treatment
GSE261760
Homo sapiens
Expression profiling by high throughput sequencing; Other
24 samples
2024/06/25
GPL21697
Summary
MYCN-amplified neuroblastoma cells exhibit upregulation of translation regulation factors and ribosome biogenesis proteins as a result of MYCN-driven transcriptional amplification. Here, we treated MYCN-amplified and non-amplified neuroblastoma cells with a novel translation inhibitor, amidino-rocaglate CMLD12824, to compare the defects in translational efficiency.
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Paper (PMID 38662542) ↗
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