← BioTransfer GEO Dataset Finder
GEO series

Liver gene expression analysis of male ApoE-/- mice treated with Isoginkgetin

GSE261858 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2024/05/15 Platform GPL17021
Summary
Isoginkgetin (ISOGK) is a biflavone derived from Ginkgo Biloba that inhibits RNA splicing. ISOGK has been reported to have various protective effects, including anti-inflammatory, antioxidant, and anti-tumorigenic properties. The study aimed to investigate the impact of ISOGK treatment on atherosclerosis induced by a Western diet in ApoE-/- mice. After seven weeks of a high-fat diet, ISOGK was administered intraperitoneally for eight weeks. At the endpoint, mice were euthanized for sample collection, and a series of indicators were tested. The study results indicate that the ISOGK treatment group significantly reduced the area of aortic plaques, aortic sinus plaques, and the necrotic core area. Additionally, ISOGK significantly lowered the levels of total cholesterol in the serum. These findings suggest that ISOGK is effective in treating atherosclerosis and reducing blood lipid levels.
Published in
A natural small molecule isoginkgetin alleviates hypercholesterolemia and atherosclerosis by targeting ACLY
Zhang Z, Chen M, Xu Y et al. · Theranostics 2025 · PMID 40225566 · doi:10.7150/thno.105782
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE261858_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 8 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1089219 and SRA study SRP496222. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 8 more — browse all 8 samples with per-sample file links →

Similar datasets

Search all mouse RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.