m6A methyltransferase Mettl3 is essential for neuronal homeostasis and sleep via modulating Npy in mice
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Mettl3-m(6)A-NPY axis governing neuron-microglia interaction regulates sleep amount of miceCell discovery · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE262033_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1090068 and SRA study SRP496708. Searching any of these in the dataset finder brings you back here.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
+ 12 more — browse all 12 samples with per-sample file links →
- GSE215759 Mettl3-dependent m6A modification is essential for effector differentiation and memory formation of CD8+ T cells [RNA-seq] 15 samples shares mettl3, essential
- GSE215762 Mettl3-dependent m6A modification is essential for effector differentiation and memory formation of CD8+ T cells 41 samples shares mettl3, essential
- GSE309618 Mesangial cell-derived extracellular matrix protein 1 is essential for maintaining mesangial matrix homeostasis and glomerular architecture 18 samples shares homeostasis, essential
- GSE328769 Alzheimer's disease associated Presenilin 2 N141I mutation impairs neuronal lipid homeostasis and mitochondrial dynamics through selective downregulation of the Golgi exchange factor Gbf1 16 samples shares homeostasis, neuronal
- GSE313112 Inhibition of METTL3 by STC-15 induces RNA misprocessing that results in dsRNA formation and activates innate immunity [RNA-Seq MC38] 69 samples shares mettl3
- GSE315612 Yiqi Huoxue Yangyin Decoction alleviates diabetic nephropathy by attenuating podocyte injury via the METTL3-m6A-mTOR pathway to activate autophagy 12 samples shares mettl3
- GSE252044 METTL3 in Diabetic Cardiomyopathy 11 samples shares mettl3
- GSE305529 METTL3-Driven RNA Modifications: A Key Mechanism and Potential Therapeutic Target in Pancreatic Acinar Cell Carcinoma in Mice [MeRIP] 48 samples shares mettl3
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.