H2A.Z reinforces maternal H3K4me3 formation and is essential for meiotic progression in mouse oocytes
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 58 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 58 samples: 18 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- H2A.Z reinforces maternal H3K4me3 formation and is essential for meiotic progression in mouse oocytesNature structural & molecular biology · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE262044_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1090085 and SRA study SRP496724. Searching any of these in the dataset finder brings you back here.
Supports a case/control comparison: 2 samples read as cases, 5 as controls.
How we read this: 18 replicated groups read from 58 sample titles; they account for 36 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8156477 H2A catch-seq FGO rep1
- GSM8156478 H2A CUT&RUN FGO rep1
- GSM8156479 H2A.X catch-seq FGO rep1
- GSM8156480 H2A.X CUT&RUN FGO rep1
- GSM8156481 TH2A catch-seq FGO rep1
- GSM8156482 TH2A CUT&RUN FGO rep1
- GSM8156483 H2A.Z 5d GO rep1 H2A.Z 5d GO
- GSM8156484 H2A.Z 5d GO rep2 H2A.Z 5d GO
- GSM8156485 H2A.Z 10d GO rep1 H2A.Z 10d GO
- GSM8156486 H2A.Z 10d GO rep2 H2A.Z 10d GO
- GSM8156487 H2A.Z 15d GO rep1 H2A.Z 15d GO
- GSM8156488 H2A.Z 15d GO rep2 H2A.Z 15d GO
- GSM8156489 H2A.Z 28d FGO rep1 H2A.Z 28d FGO
- GSM8156490 H2A.Z 28d FGO rep2 H2A.Z 28d FGO
- GSM8156491 Input 5d GO rep1
- GSM8156492 Input 10d GO rep1
- GSM8156493 Input 15d GO rep1
- GSM8156494 Input 28d FGO rep1
- GSM8156501 H2A.Z H2A.Z-CTR FGO rep1 H2A.Z H2A.Z-CTR FGO
- GSM8156502 H2A.Z H2A.Z-CTR FGO rep2 H2A.Z H2A.Z-CTR FGO
- GSM8156503 H2A.Z H2A.Z-DKO FGO rep1 H2A.Z H2A.Z-DKO FGO
- GSM8156504 H2A.Z H2A.Z-DKO FGO rep2 H2A.Z H2A.Z-DKO FGO
- GSM8156505 H3K4me3 H2A.Z-CTR FGO rep1 H3K4me3 H2A.Z-CTR FGO
- GSM8156506 H3K4me3 H2A.Z-CTR FGO rep2 H3K4me3 H2A.Z-CTR FGO
- GSM8156507 H3K4me3 H2A.Z-DKO FGO rep1 H3K4me3 H2A.Z-DKO FGO
- GSM8156508 H3K4me3 H2A.Z-DKO FGO rep2 H3K4me3 H2A.Z-DKO FGO
- GSM8156509 Input H2A.Z-CTR FGO rep1
- GSM8156510 Input H2A.Z-DKO FGO rep2
- GSM8156511 H2A.Z Mll2 WT FGO rep1 H2A.Z Mll2 WT FGO
- GSM8156512 H2A.Z Mll2 WT FGO rep2 H2A.Z Mll2 WT FGO
- GSM8156513 H2A.Z Mll2 KO FGO rep1 H2A.Z Mll2 KO FGO
- GSM8156514 H2A.Z Mll2 KO FGO rep2 H2A.Z Mll2 KO FGO
- GSM8156515 H3K4me3 Mll2 WT FGO rep1 H3K4me3 Mll2 WT FGO
- GSM8156516 H3K4me3 Mll2 WT FGO rep2 H3K4me3 Mll2 WT FGO
- GSM8156517 H3K4me3 Mll2 KO FGO rep1 H3K4me3 Mll2 KO FGO
- GSM8156518 H3K4me3 Mll2 KO FGO rep2 H3K4me3 Mll2 KO FGO
- GSM8156519 Input Mll2 WT FGO rep1
- GSM8156520 Input Mll2 KO FGO rep1
- GSM8156521 H2AK119ub1 H2A.Z-CTR FGO rep1 H2AK119ub1 H2A.Z-CTR FGO
- GSM8156522 H2AK119ub1 H2A.Z-CTR FGO rep2 H2AK119ub1 H2A.Z-CTR FGO
+ 18 more — browse all 58 samples with per-sample file links →
- GSE261412 Acute hormonal signaling-induced 3D chromatin loop reorganization controls adipocyte thermogenesis [ChIP-Seq mouse, H3K27ac, H3K4me3, H2AZ] 24 samples shares h3k4me3, h2a
- GSE222133 CUT&Tag analysis of H3K4me3, H3K27Ac,H2A119Ub and H3K27me3 in treated KPC1199 murine PDAC cell line 12 samples shares h3k4me3, h2a
- GSE229903 CUT&Tag analysis of H3K4me3, H3K27Ac,H2A119Ub, H3K27me3 and H3K36me3 in KPC1199 murine PDAC cell line 10 samples shares h3k4me3, h2a
- GSE292333 H2AK119ub1-MLL2 counteraction underlies heritable H3K27me3 formation in oocytes [CATCH-seq and CUT&RUN] 44 samples shares h2a, formation
- GSE292237 H2AK119ub1-MLL2 counteraction underlies heritable H3K27me3 formation in oocytes 43 samples shares h2a, formation
- GSE332710 Splice isoforms of the histone variants macroH2A1 differentially regulate hippocampal gene expression and memory formation 33 samples shares h2a, formation
- GSE284749 Control of Post-Meiotic Gene Expression by H2A.L.2 21 samples shares h2a, meiotic
- GSE241770 ACSS2 mediates an epigenetic pathway to regulate maternal Beta-cell adaptation and progression of gestational diabetes (scRNA-Seq) 7899 samples shares progression, maternal
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.