Control of Post-Meiotic Gene Expression by H2A.L.2
RNA-seq (gene expression) · mouse · 21 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 21 samples: 7 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- ATAD2 mediates chromatin-bound histone chaperone turnovereLife · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE284749_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1200601 and SRA study SRP552648. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 20 samples.
How we read this: 7 replicated groups read from 21 sample titles; they account for 20 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8691773 C_h2al2KO_rep1 C_h2al2KO
- GSM8691774 C_h2al2KO_rep2 C_h2al2KO
- GSM8691775 C_h2al2KO_rep3 C_h2al2KO
- GSM8691776 C_h2al2WT_rep1 C_h2al2WT
- GSM8691777 C_h2al2WT_rep2 C_h2al2WT
- GSM8691778 C_h2al2WT_rep3 C_h2al2WT
- GSM8691779 P_h2al2KO_rep1 P_h2al2KO
- GSM8691780 P_h2al2KO_rep2 P_h2al2KO
- GSM8691781 P_h2al2KO_rep3 P_h2al2KO
- GSM8691782 P_h2al2WT_rep1 P_h2al2WT
- GSM8691783 P_h2al2WT_rep2 P_h2al2WT
- GSM8691784 P_h2al2WT_rep3 P_h2al2WT
- GSM8691785 R_h2al2KO_rep1 R_h2al2KO
- GSM8691786 R_h2al2KO_rep2 R_h2al2KO
- GSM8691787 R_h2al2KO_rep3 R_h2al2KO
- GSM8691788 R_h2al2WT_rep1 R_h2al2WT
- GSM8691789 R_h2al2WT_rep2 R_h2al2WT
- GSM8691790 R_h2al2WT_rep3 R_h2al2WT
- GSM8691791 S_h2al2KO_rep1
- GSM8691792 S_h2al2WT_rep1 S_h2al2WT
- GSM8691793 S_h2al2WT_rep2 S_h2al2WT
- GSE261412 Acute hormonal signaling-induced 3D chromatin loop reorganization controls adipocyte thermogenesis [ChIP-Seq mouse, H3K27ac, H3K4me3, H2AZ] 24 samples shares h2a, control
- GSE292237 H2AK119ub1-MLL2 counteraction underlies heritable H3K27me3 formation in oocytes 43 samples shares h2a
- GSE242179 Role of the histone variant H2A.Z.1 in memory, transcription, and alternative splicing is mediated by lysine modification 40 samples shares h2a
- GSE332710 Splice isoforms of the histone variants macroH2A1 differentially regulate hippocampal gene expression and memory formation 33 samples shares h2a
- GSE247019 Cancer-associated DNA Hypermethylation of Polycomb Targets Requires DNMT3A Dual Recognition of histone H2AK119 Ubiquitination and the Nucleosome Acidic Patch 134 samples shares h2a
- GSE292333 H2AK119ub1-MLL2 counteraction underlies heritable H3K27me3 formation in oocytes [CATCH-seq and CUT&RUN] 44 samples shares h2a
- GSE273195 H2A.Z regulates memory CD8+ T cell recall response [4] 34 samples shares h2a
- GSE283201 Comparative gene expression profiling analysis of hippocampus and liver RNA-seq data for young (3-month-old) and aged (22-month-old) WT mice in both control and ethanol feeding conditions. 32 samples shares control
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.