Semaglutide ameliorates cardiac remodeling in male mice by optimizing energy substrate utilization through the Creb5/NR4a1 axis
RNA-seq (gene expression) · mouse · 21 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 21 samples: 6 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Semaglutide ameliorates cardiac remodeling in male mice by optimizing energy substrate utilization through the Creb5/NR4a1 axisNature communications · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE262105_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1090397 and SRA study SRP496913. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 21 samples.
How we read this: 6 replicated groups read from 21 sample titles; they account for 21 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8157588 Sham_1 Sham
- GSM8157589 Sham_2 Sham
- GSM8157590 Sham_3 Sham
- GSM8157591 Sham_Sema_1 Sham_Sema
- GSM8157592 Sham_Sema_2 Sham_Sema
- GSM8157593 Sham_Sema_3 Sham_Sema
- GSM8157594 TAC 8W_1 TAC 8W
- GSM8157595 TAC 8W_2 TAC 8W
- GSM8157596 TAC 8W_3 TAC 8W
- GSM8157597 TAC 8W_Sema 8W_1 TAC 8W_Sema 8W
- GSM8157598 TAC 8W_Sema 8W_2 TAC 8W_Sema 8W
- GSM8157599 TAC 8W_Sema 8W_3 TAC 8W_Sema 8W
- GSM8157600 Sham_4 Sham
- GSM8157601 Sham_5 Sham
- GSM8157602 Sham_6 Sham
- GSM8157603 Sham_Sema 4W_1 Sham_Sema 4W
- GSM8157604 Sham_Sema 4W_2 Sham_Sema 4W
- GSM8157605 Sham_Sema 4W_3 Sham_Sema 4W
- GSM8157606 TAC 8W_Sema_4W_1 TAC 8W_Sema_4W
- GSM8157607 TAC 8W_Sema_4W_2 TAC 8W_Sema_4W
- GSM8157608 TAC 8W_Sema_4W_3 TAC 8W_Sema_4W
- GSE287122 Neuregulin-1β treatment augments compensatory remodeling and ameliorates cardiac function during pressure overload 15 samples shares ameliorates, remodeling
- GSE263082 Nr4a1 regulates cell-specific transcriptional programs in inhibitory GABAergic interneurons 34 samples shares nr4a1
- GSE313371 Longitudinal transcriptomic profiling of splenic CD8 T cells in Nr4a1-KO mice during Mtb infection 24 samples shares nr4a1
- GSE266287 NR4A1 transcriptionally regulates the differentiation of stem-like CD8+ T cells in the tumor microenvironment (RNA-Seq) 18 samples shares nr4a1
- GSE281190 Creb5 controls its own expression and directly induces the joint-interzone regulatory program [RNAseq_Prx1] 12 samples shares creb5
- GSE307290 Mechanistic Study on the Restoration of Intestinal Barrier Integrity and Alleviation of Inflammatory Bowel Disease by Rhynchophylline via the AhR-NR4A1 Pathway 12 samples shares nr4a1
- GSE306798 Single-cell transcriptomic gene regulatory network analysis uncovers the alteration of colonic stem and immune cell homeostasis in Nr4a1 knockout mice 8 samples shares nr4a1
- GSE281192 Creb5 controls its own expression and directly induces the joint-interzone regulatory program 42 samples shares creb5
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.