Mechanical stretching of keloid and normal skin fibroblasts
RNA-seq (gene expression) · human · 20 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 20 samples: 10 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- CD74(+) fibroblasts proliferate upon mechanical stretching to promote angiogenesis in keloidsFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE262112_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1090087 and SRA study SRP496683. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 20 samples.
How we read this: 10 replicated groups read from 20 sample titles; they account for 20 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8157769 HFF-ctr-1 HFF-ct
- GSM8157770 HFF-ctr-2 HFF-ct
- GSM8157771 HFF-6h-1 HFF-6h
- GSM8157772 HFF-6h-2 HFF-6h
- GSM8157773 HFF-12h-1 HFF-12h
- GSM8157774 HFF-12h-2 HFF-12h
- GSM8157775 HFF-18h-1 HFF-18h
- GSM8157776 HFF-18h-2 HFF-18h
- GSM8157777 KF-ctr-1 KF-ct
- GSM8157778 KF-ctr-2 KF-ct
- GSM8157779 KF-6h-1 KF-6h
- GSM8157780 KF-6h-2 KF-6h
- GSM8157781 KF-12h-1 KF-12h
- GSM8157782 KF-12h-2 KF-12h
- GSM8157783 KF-18h-1 KF-18h
- GSM8157784 KF-18h-2 KF-18h
- GSM8157785 KF(CD74+)-ctr-1 KF(CD74+)-ct
- GSM8157786 KF(CD74+)-ctr-2 KF(CD74+)-ct
- GSM8157787 KF(CD74+)-6h-1 KF(CD74+)-6h
- GSM8157788 KF(CD74+)-6h-2 KF(CD74+)-6h
- GSE269317 Reduced WNT4 expression in normal skin fibroblasts leads to ‘Dupuytren-like’ changes in the transcriptome 16 samples shares fibroblasts, normal, skin
- GSE251807 Investigation of gene expression changes in normal human dermal fibroblasts after exposure to bone marrow mesenchymal stromal cell secretome 32 samples shares fibroblasts, normal
- GSE274709 PIEZO2 mechanoreceptor-expressing fibroblasts in keloids cause short-term recurrence after surgical resection 30 samples shares fibroblasts, keloid
- GSE330762 Kabuki syndrome type I fibroblast multi-omics dataset: bulk RNA-seq profiles from primary skin fibroblasts 19 samples shares fibroblasts, skin
- GSE231997 The use of ectopic volar fibroblasts to modify skin identity III 16 samples shares fibroblasts, skin
- GSE255684 Functional analysis and transcriptome profile of meninges and skin fibroblasts from human aged donors 15 samples shares fibroblasts, skin
- GSE316921 Effects of SLC2A1 knockdown in intrahepatic cholangiocarcinoma (ICC) cancer-associated fibroblasts (CAFs) on endothelial sprouting under normal and hypoxic conditions 12 samples shares fibroblasts, normal
- GSE280564 Reprogramming of normal fibroblasts into ovarian cancer-associated fibroblasts via non-vesicular paracrine signaling induces an activated fibroblast phenotype 12 samples shares fibroblasts, normal
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.