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Gene expression profiling of lung tissues comparing between Ism1-/- and Wildtype mice at postnatal day 7 (P7) stage

GSE262122 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2024/06/11 Platform GPL24247
Summary
Isthmin 1 (ISM1) is a secreted protein of 60 kDa which has known functions of anti-apoptosis and anti-angiogenesis. To understand the physiological functions of ISM1, we generated Ism1 knockout (Ism1-/-) mice in C57BL/6J background through CRISPR gene editing technology. Under normal conditions, Ism1-/- mice presented spontaneous and progressive lung emphysema with enhanced immune cell infiltration compared to wildtype mice suggesting the role of ISM1 in pulmonary inflammation. In order to understand the pathways perturbed in the Ism1-/- mice, bulk RNA-sequencing analysis was performed using total RNA isolated from the lungs of WT and Ism1-/- mice at post-natal day 7 (P7) stage, when the process of alveolarization occurs.
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Direct links to NCBI, no account and no request form: the whole study as GSE262122_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1090424 and SRA study SRP496967. Searching any of these in the dataset finder brings you back here.

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