Targeting GI-SINE (Growth inducing B2-SINE) RNA in DRG neurons by Antisense Oligonucleotides (ASO)
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 4 × DRG culture, ASO Control 50nM vs 4 × DRG culture, ASO mix 50nM vs 4 × DRG culture, untransfectedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE262153_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1090485 and SRA study SRP497030. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 3 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8158816 DRG culture, ASO Control 50nM replicate 1 DRG culture, ASO Contro…
- GSM8158817 DRG culture, ASO Control 50nM replicate 2 DRG culture, ASO Contro…
- GSM8158818 DRG culture, ASO Control 50nM replicate 3 DRG culture, ASO Contro…
- GSM8158819 DRG culture, ASO Control 50nM replicate 4 DRG culture, ASO Contro…
- GSM8158820 DRG culture, ASO mix 50nM replicate 1 DRG culture, ASO mix 50…
- GSM8158821 DRG culture, ASO mix 50nM replicate 2 DRG culture, ASO mix 50…
- GSM8158822 DRG culture, ASO mix 50nM replicate 3 DRG culture, ASO mix 50…
- GSM8158823 DRG culture, ASO mix 50nM replicate 4 DRG culture, ASO mix 50…
- GSM8158824 DRG culture, untransfected replicate 1 DRG culture, untransfec…
- GSM8158825 DRG culture, untransfected replicate 2 DRG culture, untransfec…
- GSM8158826 DRG culture, untransfected replicate 3 DRG culture, untransfec…
- GSM8158827 DRG culture, untransfected replicate 4 DRG culture, untransfec…
- GSE279906 Role of ATF3 in the transcription of GI-SINEs (growth inducing B2-SINEs) in DRG neurons in response to sciatic nerve crush 34 samples shares gi-sine, b2-sine, drg, inducing
- GSE266962 Targeting Immunoproteasome in Macrophages Suppresses M1 Polarization and Ameliorates Experimental Emphysema via Activating NRF1 and NRF2-P62 Axis 24 samples shares aso, targeting
- GSE290262 Transcriptome of rNLS8 mice and controls injected with non-targeting control ASO 21 samples shares aso, targeting
- GSE261670 ASOs are an effective treatment for disease-associated oligodendrocyte signatures in premanifest and symptomatic SCA3 mice 74 samples shares aso
- GSE275643 Single cell RNA-seq reveals GINIP-Expressing neurons as the main targets of focused ultrasoud. 57 samples shares aso
- GSE254406 A pan-family screen of Nuclear Receptors in immunocytes reveals ligand-dependent inflammasome control [RNA-seq 1] 52 samples shares aso
- GSE251784 ECM29/Proteasome-Mediated Self-Antigen Generation by CNS-Resident Neuroglia Promotes Regulatory T Cell Activation 47 samples shares aso
- GSE326336 CRISPR/Cas9 screening reveals key role of STK11/LKB1 in vasopressin-mediated regulation of Aqp2 transcription 44 samples shares aso
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.