GEO series
Elevated choline drives KLF5-dominated transcriptional reprogramming to facilitate liver cancer progression
GSE262272
Homo sapiens
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
12 samples
2024/09/04
GPL24676
Summary
We provide evidence highlighting a novel mechanism by which choline remodels CRC and upregulate the SE-driven key transcription factor KLF5 via the methyl donor pathway, implicating potential therapeutic targets in HCC.
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Paper (PMID 39251845) ↗
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