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Identification and Targeting of Regulators of SARS-CoV-2-Host interactions in the Airway Epithelium [scRNA-Seq]

GSE262298 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2025/05/18 Platform GPL24676
Summary
The conducting airway epithelium is the first line of defense in the respiratory tract against pathogens and a prime site of SARS-CoV-2 viral entry, serving to maintain a high viral load during lung infection. The impact of SARS-CoV-2 infection in the respiratory epithelium has been extensively studied. However, still less is known about the regulators of SARS-Cov-2-induced programs that facilitate infection and viral replication in distinct human airway epithelial cell populations, such as basal, secretory, and multiciliated cells. Here, we used SARS-CoV-2-infection of human airway epithelial organotypic cultures, single cell transcriptomics, large FDA-approved drug perturbation profiles combined with Master Regulator analysis to identify host cell defense and response pathways determinants of viral infection
Published in
Identification and targeting of regulators of SARS-CoV-2-host interactions in the airway epithelium
Dirvin B, Noh H, Tomassoni L et al. · Science advances 2025 · PMID 40378209 · doi:10.1126/sciadv.adu2079
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Also filed as BioProject PRJNA1091174 and SRA study SRP497401. Searching any of these in the dataset finder brings you back here.

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