MYT1L deficiency impairs excitatory neuron trajectory during cortical development
RNA-seq (gene expression) · mouse · 42 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 42 samples: 42 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- MYT1L deficiency impairs excitatory neuron trajectory during cortical developmentNature communications · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE262368_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1091594 and SRA study SRP497619. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 42 sample titles: 42 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8163923 E14 WT, replicate 1, run 1, snRNAseq
- GSM8163924 E14 WT, replicate 2, run 1, snRNAseq
- GSM8163925 E14 WT, replicate 3, run 1, snRNAseq
- GSM8163926 E14 Het, replicate 1, run 1, snRNAseq
- GSM8163927 E14 Het, replicate 2, run 1, snRNAseq
- GSM8163928 E14 Het, replicate 3, run 1, snRNAseq
- GSM8163929 E14 KO, replicate 1, run 1, snRNAseq
- GSM8163930 E14 KO, replicate 2, run 1, snRNAseq
- GSM8163931 E14 KO, replicate 3, run 1, snRNAseq
- GSM8163932 E14 WT, replicate 1, run 2, snRNAseq
- GSM8163933 E14 WT, replicate 2, run 2,snRNAseq
- GSM8163934 E14 WT, replicate 3, run 2,snRNAseq
- GSM8163935 E14 Het, replicate 1, run 2,snRNAseq
- GSM8163936 E14 Het, replicate 2, run 2,snRNAseq
- GSM8163937 E14 Het, replicate 3, run 2,snRNAseq
- GSM8163938 E14 KO, replicate 1, run 2,snRNAseq
- GSM8163939 E14 KO, replicate 2, run 2,snRNAseq
- GSM8163940 E14 KO, replicate 3, run 2,snRNAseq
- GSM8163947 P21 WT, male, replicate 1, snRNAseq
- GSM8163948 P21 WT, male, replicate 2, snRNAseq
- GSM8163949 P21 WT, male, replicate 3, snRNAseq
- GSM8163950 P21 WT, female, replicate 1, snRNAseq
- GSM8163951 P21 WT, female, replicate 2, snRNAseq
- GSM8163952 P21 WT, female, replicate 3, snRNAseq
- GSM8163953 P21 Het, male, replicate 1, snRNAseq
- GSM8163954 P21 Het, male, replicate 2, snRNAseq
- GSM8163955 P21 Het, male, replicate 3, snRNAseq
- GSM8163956 P21 Het, female, replicate 1, snRNAseq
- GSM8163957 P21 Het, female, replicate 2, snRNAseq
- GSM8163958 P21 Het, female, replicate 3, snRNAseq
- GSM8443437 P1 WT, male, replicate 1, snRNAseq
- GSM8443438 P1 WT, male, replicate 2, snRNAseq
- GSM8443439 P1 WT, male, replicate 3, snRNAseq
- GSM8443440 P1 WT, male, replicate 4, snRNAseq
- GSM8443441 P1 WT, male, replicate 5, snRNAseq
- GSM8443442 P1 WT, female, replicate 1, snRNAseq
- GSM8443443 P1 WT, female, replicate 2, snRNAseq
- GSM8443444 P1 WT, female, replicate 3, snRNAseq
- GSM8443445 P1 Het, male, replicate 1, snRNAseq
- GSM8443446 P1 Het, male, replicate 2, snRNAseq
+ 2 more — browse all 42 samples with per-sample file links →
- GSE300997 Persistent cortical excitatory neuron dysregulation in adult Chd8 haploinsufficient mice 127 samples shares excitatory, cortical, neuron
- GSE335970 KMT2C catalytic activity regulates enhancer H3K4me1 and synaptic gene expression in cortical excitatory neurons [RNA-Seq] 39 samples shares excitatory, cortical, neuron
- GSE293592 Maternal immune activation delays DNA methylation and physiological maturation of cortical excitatory neurons 106 samples shares excitatory, cortical, neuron
- GSE336091 KMT2C catalytic activity regulates enhancer H3K4me1 and synaptic gene expression in cortical excitatory neurons [CUT&Tag] 48 samples shares excitatory, cortical, neuron
- GSE260623 Germline ELP1 deficiency sensitizes cerebellar granule neuron progenitors to SHH medulloblastoma [bulkRNA] 91 samples shares deficiency, neuron
- GSE325852 Translatome profiling reveals opposing alterations in inhibitory and excitatory neurons of Fragile X mice and identifies EPAC2 as a therapeutic target 69 samples shares excitatory, neuron
- GSE326648 Sexual dimorphism shapes AAK trajectory in Pax6 deficiency mouse model with early immune activation, impaired innervation, and altered tears 40 samples shares deficiency, trajectory
- GSE291086 Neuronal ABCA7 deficiency aggravates mitochondrial dysfunction and neurodegeneration in Alzheimer’s disease 24 samples shares deficiency, neuron
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.