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A Scaffolding Element Rewires Local 3D Chromatin Architecture During Differentiation

GSE262551 Mus musculus (mouse) ChIP-seq / ATAC-seq (genome binding and open chromatin) 255 samples Submitted 2024/05/23 Platform GPL28457Platform GPL24247
At a glance

ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 255 samples

What it is
ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
Organism
Mus musculus (mouse)
Samples
255 samples: 119 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
SuperSeries — this record groups several sub-series.
Summary (written by the submitters)
This SuperSeries is composed of the SubSeries listed below.
This dataset
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE262551_RAW.tar (it can run to tens of gigabytes).

3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.

Also filed as BioProject PRJNA1083571 and SRA study SRP493257. Searching any of these in the dataset finder brings you back here.

Study design
119 conditions, mostly in duplicate
cHiC of wt mouse ESC at the Zfp608 locus ×2 cHiC of Zfp608 promoter deletion in mouse ESC… ×2 cHiC of polyA insertion at Zfp608 in mouse ES… ×2 cHiC of element A deletion in mouse ESC at th… ×2 cHiC of element B deletion in mouse ESC at th… ×2 cHiC of element A and B deletion in mouse ESC… ×2 cHiC of CTCF motif deletion at element A in m… ×2 cHiC of Pax6 upregulation in mouse ESC at the… ×2 +128 more

Supports a between-group comparison across 238 samples.

How we read this: 119 replicated groups read from 255 sample titles; they account for 238 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study

+ 215 more — browse all 255 samples with per-sample file links →

Datasets on a similar topic

Search all mouse RNA-seq datasets in GEO →

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