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Spatial chromatin architecture and accessibility co-profiling of mammalian tissues

GSE307620 Mus musculus Other 2 samples Submitted 2026/07/01 Platform GPL34290
Summary
Recent advancements of spatial omics techniques have enabled the profiling of different molecular features with spatial information. We developed Spatial-ATAC-Hi-C, which can provide spatially resolved, genome-wide joint-profiling of 3D genome organization and chromatin accessibility on tissue slides. Applying Spatial-ATAC-Hi-C in mouse and human brains, we revealed distinct chromatin architecture features and gene regulatory programs of different types of neuron and non-neuron cells in their original tissue locations.
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Also filed as BioProject PRJNA1322418. Searching any of these in the dataset finder brings you back here.

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