LAG3 and PD1 synergize on CD8+ T cells to drive T cell exhaustion and hinder autocrine IFN gamma-dependent anti-tumor immunity

Direct links to NCBI, no account and no request form: the whole study as GSE262740_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 5 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1093086 and SRA study SRP498546. Searching any of these in the dataset finder brings you back here.

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• GSE234186 Lymphatic-localized Treg-mregDC crosstalk limits antigen trafficking and restrains anti-tumor immunity 26 samples
• GSE336756 Compartmentalisation of m6A (N6-methyladenosine) methylated RNA in somatic or axonal subcellular locations is dependent on Nerve Growth Factor (NGF) state in sympathetic neurons [Axon-meRIP-seq] 32 samples
• GSE270050 Expansion of Tumor-Infiltrating CD8+ T Cell Clonotypes Occurs in the Spleen in Response to Immune Checkpoint Blockade 29 samples
• GSE281706 Omental support of ovarian tumor cell growth is unabated in the absence of mature adipocytes 24 samples
• GSE318707 ST8Sia6-dependent glycosylation restrains gut inflammation and pathogenic Th1 and Th17 programs 18 samples
• GSE317032 Non-cytolytic viral vaccine vectors induce durable effector-memory CD8 T cell immunity by triggering type I interferon 18 samples
• GSE327213 Increased mRNA translation delays tumor initiation and exposes a therapeutic vulnerability in lung cancer 16 samples
• GSE251931 Maintenance of tolerance after lung transplantation is dependent on the preservation of allograft tissue-resident Foxp3+ T cells 15 samples

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