ST8Sia6-dependent glycosylation restrains gut inflammation and pathogenic Th1 and Th17 programs
Single-cell RNA-seq · mouse · 18 samples
- What it is
- Single-cell RNA-seqGene activity measured in thousands of individual cells, so cell types can be told apart. Read from the summary: GEO's own type field only says 'expression profiling by sequencing', so confirm it in the paper.
- Organism
- Mus musculus (mouse)
- Samples
- 18 samples: 6 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- ST8Sia6-dependent glycosylation restrains gut inflammation and pathogenic T(h)1 and T(h)17 programsCell reports · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE318707_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA1419813 and SRA study SRP675319. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 18 samples.
How we read this: 6 replicated groups read from 18 sample titles; they account for 18 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9501071 GEX_SB-EP GEX_SB-EP
- GSM9501072 GEX_SB-LP GEX_SB-LP
- GSM9501073 GEX_Colons GEX_Colons
- GSM9501074 CITE_SB-EP CITE_SB-EP
- GSM9501075 CITE_SB-LP CITE_SB-LP
- GSM9501076 CITE_Colons CITE_Colons
- GSM9501077 GEX_SB-EP2 GEX_SB-EP
- GSM9501078 GEX_SB-LP2 GEX_SB-LP
- GSM9501079 GEX_Colons2 GEX_Colons
- GSM9501080 CITE_SB-EP2 CITE_SB-EP
- GSM9501081 CITE_SB-LP2 CITE_SB-LP
- GSM9501082 CITE_Colons2 CITE_Colons
- GSM9501083 GEX_SB-EP3 GEX_SB-EP
- GSM9501084 GEX_SB-LP3 GEX_SB-LP
- GSM9501085 GEX_Colons3 GEX_Colons
- GSM9501086 CITE_SB-EP3 CITE_SB-EP
- GSM9501087 CITE_SB-LP3 CITE_SB-LP
- GSM9501088 CITE_Colons3 CITE_Colons
- GSE296201 A20’s Linear Ubiquitin Binding Motif Restrains Pathogenic Activation of TH17/22 cells and IL-22 Driven Enteritis [RNA-Seq] 18 samples shares th17, pathogenic, restrains
- GSE296200 A20’s Linear Ubiquitin Binding Motif Restrains Pathogenic Activation of TH17/22 cells and IL-22 Driven Enteritis [ATAC-seq] 11 samples shares th17, pathogenic, restrains
- GSE290297 Population RNA-seq from Th17 cells differentiated in vitro under pathogenic (Th17p) and non-pathogenic (Th17n) conditions with DHEA or EGCG 79 samples shares th17, pathogenic
- GSE285450 Fructose specifically exacerbates pathogenic-Th17 cell differentiation and autoimmune diseases through ROS-EGFR signal 18 samples shares th17, pathogenic
- GSE298306 Immune-responsive gene-1: The mitochondrial Key to Th17 Cell Pathogenicity in CNS Autoimmunity 18 samples shares th17, pathogenic
- GSE306371 Unconventional role of HMGCS1 in driving pathogenic-Th17 cell immunity and autoimmune diseases 16 samples shares th17, pathogenic
- GSE284714 AMPK signaling downstream of adenosine 2A receptor represses Th17 cell pathogenicity through epigenetic and metabolic reprogramming. 15 samples shares th17, pathogenic
- GSE326921 The chromatin assembly factor CHAF1b functions as an epigenetic amplifier of RORγt to promote Th17 pathogenicity and autoimmunity 13 samples shares th17, pathogenic
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.