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ST8Sia6-dependent glycosylation restrains gut inflammation and pathogenic Th1 and Th17 programs

GSE318707 Mus musculus Expression profiling by high throughput sequencing; Other 18 samples 2026/03/22 GPL24247
Summary
Single-cell suspensions of small bowel lamina propria, small bowel epithelium, and whole colon were purified from mice sufficient, deficient, and heterozygous for sialic acid transferase ST8Sia6. Cells were enriched for CD45 expression, hashtagged according to genotype, and analyzed by 10x scRNA sequencing using the Illumina Novaseq 6000 as well as by 10X CITEseq to identify hashtags.
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