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Transcriptome analysis of neuronal-like cells conversed from U251 cells incubated with SLCDS

GSE262741 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/08/17 Platform GPL24676
Summary
Glioma, the most common primary tumor in the central nervous system, presents significant challenges in treatment. Researchers are now investigating novel approaches to convert glioma cells into functional neurons. This study explores the conversion process using a combination of small molecule compounds (SLCDS) and examines the underlying mechanisms. Results demonstrate that SLCDS effectively transforms human glioma cells into mature neurons while suppressing markers associated with glioma malignancy. Upregulation of neuronal transcription factors and inhibition of glioma proliferation, angiogenesis, invasion, and metastasis are observed with SLCDS treatment. These findings suggest a promising therapeutic strategy for glioma treatment.
Published in
Conversion of glioma cells into neuron-like cells by small molecules
Yi Y, Che W, Xu P et al. · iScience 2024 · PMID 39483145 · doi:10.1016/j.isci.2024.111091
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Also filed as BioProject PRJNA1093085 and SRA study SRP498504. Searching any of these in the dataset finder brings you back here.

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