← BioTransfer GEO Dataset Finder
GEO series

Unveiling the Anti-Aging Potential of 3HB: Lifespan Extension, Healthy Life Improvement, and Cellular Senescence Delay

GSE262770 Mus musculus Expression profiling by high throughput sequencing 9 samples Submitted 2025/06/04 Platform GPL13112
Summary
Aging is a significant risk factor for chronic diseases and disability, yet effective anti-aging interventions remain elusive. We explored the potential of 3-hydroxybutyrate (3HB), an endogenous metabolite with established safety, to modulate longevity in mice. Our findings demonstrate that 3HB supplementation effectively delays cellular senescence, extending yeast lifespan by 51.3% and the median lifespan of naturally senescent mice by 21.0%. Notably, 3HB prolonged healthy lifespan in mice while mitigating age-related tissue morphology changes and organ senescence. Mechanistically, we identified that 3HB's anti-aging properties are mediated through its ability to delay cellular senescence and metabolic reprogramming, while promoting the production of beneficial metabolites like trigoneline and isoguvacine. These findings highlight the promising therapeutic potential of 3HB as an anti-aging intervention and provide novel insights into its underlying mechanisms.
Published in
Unveiling the Anti-Aging Potential of 3HB: Lifespan Extension and Cellular Senescence Delay
An Y, Wang Q, Qiao P et al. · Nutrients 2025 · PMID 40431385 · doi:10.3390/nu17101647
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE262770_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 9 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1093150 and SRA study SRP498524. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 9 more — browse all 9 samples with per-sample file links →

Similar datasets

Search all mouse RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.