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HNF4α is a target of the Wnt/β-catenin pathway and regulates colorectal carcinogenesis

GSE262785 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2026/06/01 Platform GPL24676
Summary
Hepatocyte nuclear factor 4alpha (HNF4α) is a transcription factor involved in liver function. Dysregulation of HNF4α leads to hepatocarcinogenesis. However, the role and mechanism of HNF4α in colorectal cancer is still unknown. Here we demonstrate that HNF4α is upregulated in colorectal cancers. and HNF4α upregulation promotes colorectal tumorigenesis. Notably, expression levels of HNF4α are positively correlated with the Wnt/β-catenin signaling pathway in colorectal cancer patients. Further, we showed that HNF4α is transcriptionally activated by Wnt/β-catenin/TCF3 and is at least partially responsible for the oncognesis activity of the Wnt signaling in colorectal cancer. Our findings indicate that HNF4α is a direct target of that Wnt/β-catenin pathway and could play an important role in colorectal carcinogenesis.
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Also filed as BioProject PRJNA1093378 and SRA study SRP498632. Searching any of these in the dataset finder brings you back here.

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