Discovery and Anti-inflammatory Activity of a Cyanobacterial Macrolide Glycoside Targeting the Keap1/Nrf2 Pathway
RNA-seq (gene expression) · human · 14 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 14 samples: 7 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Isolation and Characterization of the Cyanobacterial Macrolide Glycoside Moorenaside, an Anti-Inflammatory Analogue of Aurisides Targeting the Keap1/Nrf2 PathwayJournal of natural products · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE262850_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1093481 and SRA study SRP498755. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 14 samples.
How we read this: 7 replicated groups read from 14 sample titles; they account for 14 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8180488 control_lm_rep1 control_lm
- GSM8180489 control_lm_rep2 control_lm
- GSM8180490 control_m_rep1 control_m
- GSM8180491 control_m_rep2 control_m
- GSM8180492 Auriside_m32_rep1 Auriside_m32
- GSM8180493 Auriside_m32_rep2 Auriside_m32
- GSM8180494 Auriside_m10_rep1 Auriside_m10
- GSM8180495 Auriside_m10_rep2 Auriside_m10
- GSM8180496 control_h_rep1 control_h
- GSM8180497 control_h_rep2 control_h
- GSM8180498 Auriside_h32_rep1 Auriside_h32
- GSM8180499 Auriside_h32_rep2 Auriside_h32
- GSM8180500 Auriside_h10_rep1 Auriside_h10
- GSM8180501 Auriside_h10_rep2 Auriside_h10
- GSE279100 Differential KEAP1/NRF2-mediated signaling widens the therapeutic window of redox-targeting drugs in SCLC therapy [seq] 50 samples shares keap1, nrf2, targeting
- GSE280643 Differential KEAP1/NRF2-mediated signaling widens the therapeutic window of redox-targeting drugs in SCLC therapy 74 samples shares keap1, nrf2, targeting
- GSE263043 Combined antagonism of Interleukin 6 and Oncostatin M provide both anti-inflammatory and anti-fibrotic benefit in pulmonary fibrosis 171 samples shares anti-inflammatory
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.