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scRNA-seq of lymph node stromal cells from naïve mice and heart allograft transplanted mice with/without anti-CD40L

GSE262918 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/04/02 Platform GPL24247
Summary
Lymph node stromal cells (LNSCs) are the master regulator of the LN microenvironment. Single-cell genomics has revealed a multitude of LNSCs subsets, each playing unique and critical roles in immune responses and tissue homeostasis. However, the role of specific LNSC subsets controlling tolerance within draining LNs (DLNs) in heart allograft transplanted recipients remains to be explored. In order to assess the phenotype of LNSCs and effect of LNSCs on transplant tolerance or allograft rejection after heart transplantation, we performed single cell RNA sequencing (scRNA-seq) of LNSCs from naive mice and heart allograft transplanted mice with/without anti-CD40L (day8 after heart transplantation, anti-CD40L (250 μg, day 0)).
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Direct links to NCBI, no account and no request form: the whole study as GSE262918_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1094903 and SRA study SRP499008. Searching any of these in the dataset finder brings you back here.

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