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Effect of tweak stimulation on primary lung fibroblasts

GSE262923 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2025/01/20 Platform GPL24247
Summary
TWEAK, also known as TNFSF12, is a multifunctional cytokine that controls many cellular activities in tissue repair and disease by binding to its receptor Fn14.TWEAK-Fn14 signaling has been shown to induce canonical and noncanonical NFkB signaling, triggering pro-inflammatory responses and leukocyte infiltration.We found that TWEAK-Fn14 signaling was upregulated in IPF while Fn14 was mainly expressed in fibroblasts. Therefore, we added different concentrations of TWEAK to primary mouse lung fibroblasts to activate the TWEAK-Fn14 signaling pathway, and explored the transcriptome changes of TWEAK-Fn14 signaling pathway activation in fibroblasts by RNA-seq technology.
Published in
TWEAK-Fn14 signaling protects mice from pulmonary fibrosis by inhibiting fibroblast activation and recruiting pro-regenerative macrophages
Liu L, Wu P, Wei Y et al. · Cell reports 2025 · PMID 39827460 · doi:10.1016/j.celrep.2024.115220
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Also filed as BioProject PRJNA1094915 and SRA study SRP499006. Searching any of these in the dataset finder brings you back here.

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