RNA-seq of NSC-34 cells expressing SOD1
RNA-seq (gene expression) · mouse · 10 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 10 samples: 10 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Unveiling the double-edged sword: SOD1 trimers possess tissue-selective toxicity and bind septin-7 in motor neuron-like cellsStructure (London, England : 1993) · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE263048_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1095516 and SRA study SRP499384. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 10 sample titles: 10 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8184478 NSC-34 cells transfected with SOD1 WT 24 hrs
- GSM8184479 NSC-34 cells transfected with SOD1 WT 48 hrs
- GSM8184480 NSC-34 cells transfected with SOD1 A4V 24 hrs
- GSM8184481 NSC-34 cells transfected with SOD1 A4V 48 hrs
- GSM8184482 NSC-34 cells transfected with SOD1 FH 24 hrs
- GSM8184483 NSC-34 cells transfected with SOD1 FH 48 hrs
- GSM8184484 NSC-34 cells transfected with SOD1 HG 24 hrs
- GSM8184485 NSC-34 cells transfected with SOD1 HG 48 hrs
- GSM8184486 NSC-34 cells transfected with SOD1 DI 24 hrs
- GSM8184487 NSC-34 cells transfected with SOD1 DI 48 hrs
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Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.