GEO series
Effect of liver-specific deletion of Gclc, Nrf2, and Gclc-Nrf2 on the liver
GSE263119
Mus musculus
Expression profiling by high throughput sequencing
16 samples
2024/05/29
GPL24247
Summary
The rate-limiting step in glutathione (GSH) synthesis is controlled by glutamate-cysteine ligase catalytic subunit. GSH is reported to buffer oxidative stress. In the absence of GSH, the antioxidant transcription factor Nrf2 is reported to be stabilized. The liver has the highest levels of GSH, but its impact on liver homeostasis is unclear. To investigate this, we induced a liver-specific deletion of Gclc (Gclc f/f), Nrf2 (Nrf2 f/f), or Gclc-Nrf2 (Gclc f/f Nrf2 f/f) by injecting my via tail-vein with AAV-TBG-Cre, which induces recombination specifically in hepatocytes.
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Paper (PMID 39034312) ↗
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