Intravenous chaperone treatment of late-stage Alzheimer's disease (AD) mouse model affects amyloid plaque load, reactive gliosis and AD related genes
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 3 × WT_Veh vs 3 × WT_BRICHOS vs 3 × APP_Veh vs 3 × APP_BRICHOSGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Intravenous chaperone treatment of late-stage Alzheimer´s disease (AD) mouse model affects amyloid plaque load, reactive gliosis and AD-related genesTranslational psychiatry · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE263166_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1096025 and SRA study SRP499639. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8187055 WT_Veh_1 WT_Veh
- GSM8187056 WT_Veh_2 WT_Veh
- GSM8187057 WT_Veh_3 WT_Veh
- GSM8187058 WT_BRICHOS_1 WT_BRICHOS
- GSM8187059 WT_BRICHOS_2 WT_BRICHOS
- GSM8187060 WT_BRICHOS_3 WT_BRICHOS
- GSM8187061 APP_Veh_1 APP_Veh
- GSM8187062 APP_Veh_2 APP_Veh
- GSM8187063 APP_Veh_3 APP_Veh
- GSM8187064 APP_BRICHOS_1 APP_BRICHOS
- GSM8187065 APP_BRICHOS_2 APP_BRICHOS
- GSM8187066 APP_BRICHOS_3 APP_BRICHOS
- GSE304212 Molecular Pathogenesis of Alzheimer's Disease Onset in a Mouse Model: Effects of Cannabidiol Treatment 60 samples shares treatment, alzheimer
- GSE243110 A TrkB and TrkC partial agonist prevents synaptic plasticity deficits and elicits activity-dependent synaptic and microglial transcriptomic changes in a late-stage Alzheimer’s disease mouse model 36 samples shares late-stage, alzheimer
- GSE249630 Modeling T cell temporal response to cancer immunotherapy rationalize development of combinatorial treatments protocols 1372 samples shares treatment
- GSE332646 Bulk RNA-seq of juvenile mouse liver following NDMA or saline treatment in WT and Mgmt-/- genotypes across multiple timepoints 214 samples shares treatment
- GSE294630 CDA HFD mice analysed for hepatic gene expression after treatment with semaglutide 97 samples shares treatment
- GSE245728 GLP-1 directed NMDA receptor antagonism for obesity treatment 87 samples shares treatment
- GSE235623 MERTK inhibition for the treatment of tissue fibrosis [RNA-seq] 86 samples shares treatment
- GSE294629 DIO-MASH mice analysed for hepatic gene expression after treatment with semaglutide 77 samples shares treatment
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.