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Comparing the transcriptome expression differences between breast cancer cells EO771-tdT-Parental and EO771-tdT-LM2 using high-throughput sequencing.

GSE263184 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/04/03 Platform GPL24247
Summary
The molecular mechanisms that regulate breast cancer cell (BCC) metastasis and proliferation within the leptomeninges (LM) are poorly understood, limiting development of effective therapies. Here we show that BCCs in mice can invade the LM by abluminal migration along blood vessels that connect vertebral/calvarial bone marrow and meninges, bypassing the blood-brain barrier. To screen for signaling pathways in EO-LM2 cells that could support their survival or proliferation in the meningeal niche, we performed RNA-seq analysis of EO771-tdT-Parental and EO771-tdT-LM2 to compare their transcriptome expression differences.
Published in
Breast cancer exploits neural signaling pathways for bone-to-meninges metastasis
Whiteley AE, Ma D, Wang L et al. · Science (New York, N.Y.) 2024 · PMID 38900896 · doi:10.1126/science.adh5548
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Also filed as BioProject PRJNA1096053 and SRA study SRP499623. Searching any of these in the dataset finder brings you back here.

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