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Obesity Disrupts the Pituitary-Hepatic UPR Communication Leading to NAFLD Progression (pituitary scRNA seq)

GSE263189 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2024/04/30 Platform GPL24247
Summary
Obesity alters circulating levels of pituitary hormones that govern hepatic immune-metabolic homeostasis, and dysregulation of which leads to NAFLD. Here, using diet induced obese and IRE1PKO mice, we uncovered an blunted unfolded protein response (UPR) but elevated inflammatory signatures in pituitary glands of obese mice. Mechanistically, we demonstrated that the pituitary IRE1alpha-XBP1 UPR branch is essential for protecting against pituitary endocrine defects and NAFLD progression in obesity.
Published in
Obesity disrupts the pituitary-hepatic UPR communication leading to NAFLD progression
Qian Q, Li M, Zhang Z et al. · Cell metabolism 2024 · PMID 38718793 · doi:10.1016/j.cmet.2024.04.014
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Also filed as BioProject PRJNA1096109 and SRA study SRP499653. Searching any of these in the dataset finder brings you back here.

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