GEO series
Inducible intestinal epithelial knockout of PRMT1 in mouse model
GSE263245
Mus musculus
Expression profiling by high throughput sequencing
18 samples
2025/05/12
GPL24247
Summary
Many studies investigated the mechanisms that control enteroendocrine cell (EEC) fate determination; however, regulation of EEC development and function are still unclear. Here, We performed RNA-Sequencing analyses on the small intestinal crypts of tamoxifen-inducible intestinal epithelium-specific knockout of PRMT1 and wildtype mice. Our finding for the first time revealed that the epigenetic enzyme PRMT1 controls mouse enteroendocrine cell differentiation, which probably via inhibition of Neurogenin 3-mediated commitment to the EEC lineage.
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