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Integrin αV as a potential target in aortic aneurysm and dissection

GSE263304 Mus musculus (mouse) RNA-seq (gene expression) 14 samples Submitted 2025/11/23 Platform GPL24247

At a glance

RNA-seq (gene expression) · mouse · 14 samples

What it is: RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
Organism: Mus musculus (mouse)
Samples: 14 samples: 4 × BAPN vs 4 × BAPN+SB273005 vs 3 × PBS vs 3 × BAPN+CilengitideGroups are read from the sample names, not from the paper. Check the list below.
Data you can get: A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper: Integrin αV emerges as a potential therapeutic target with cautionary implications in thoracic aortic aneurysm and dissectionThe Journal of thoracic and cardiovascular surgery · 2026

Summary (written by the submitters)

Thoracic aortic aneurysm (TAA) is a perilous disease that can lead to aortic dissection (AD), the pathophysiological mechanisms of which remain largely elusive. To improve our understanding of the molecular mechanism underlying TAA, we conducted a tandem mass tag (TMT)-based proteomics analysis and identified two down-regulated proteins, integrin αV, and integrin αL, in serum samples from patients with type A aortic dissection.

Read the full summary ↓

We confirmed that integrin αV is extensively expressed in the aortic media, and its expression decreases after dissection, whereas the expression of integrin αL showed no significant alteration. Subsequently, by employing a mouse model of TAA induced by β-Aminopropionitrile (BAPN), we discovered that the mice treated with integrin αV inhibitors Cilengitide or SB273005 developed dramatically expansive ascending TAA, accompanied by exacerbated disorganization or loss of elastic fibers. Bulk RNA sequencing results further indicated that the treatment with integrin αV inhibitors exacerbates the pro-inflammatory response in mouse TAA development. These data suggest that integrin αV may be a novel target for TAA intervention. However, it also raises concerns about exposure to integrin αV inhibitors, which are conducted in serious cancer clinical trials, may pose a potential risk of developing aortic aneurysm (AA)/AD.

Published in

Integrin αV emerges as a potential therapeutic target with cautionary implications in thoracic aortic aneurysm and dissection

Su SA, Zhu Y, Feng Z et al. · The Journal of thoracic and cardiovascular surgery 2026 · PMID 41077125 · doi:10.1016/j.jtcvs.2025.10.006

This dataset

Open GSE263304 in finder → Find more mouse RNA-seq datasets →

Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓

2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE263304_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓

3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.

Also filed as BioProject PRJNA1096678 and SRA study SRP499951. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 41077125) ↗

Study design

4 × BAPN vs 4 × BAPN+SB273005 vs 3 × PBS vs 3 × BAPN+Cilengitide

Supports a between-group comparison across 14 samples.

How we read this: 4 replicated groups read from 14 sample titles; they account for 14 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study

GSM8189360 PBS-1 PBS
GSM8189361 PBS-2 PBS
GSM8189362 PBS-3 PBS
GSM8189363 BAPN-1 BAPN
GSM8189364 BAPN-2 BAPN
GSM8189365 BAPN-3 BAPN
GSM8189366 BAPN-4 BAPN
GSM8189367 BAPN+Cilengitide-1 BAPN+Cilengitide
GSM8189368 BAPN+Cilengitide-2 BAPN+Cilengitide
GSM8189369 BAPN+Cilengitide-3 BAPN+Cilengitide
GSM8189370 BAPN+SB273005-1 BAPN+SB273005
GSM8189371 BAPN+SB273005-2 BAPN+SB273005
GSM8189372 BAPN+SB273005-3 BAPN+SB273005
GSM8189373 BAPN+SB273005-4 BAPN+SB273005

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