Imbalanced TGF-beta signalling and autophagy drive erythroid priming of hematopoietic stem cells in Beta-thalassemia
RNA-seq (gene expression) · human · 20 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 20 samples: 10 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Imbalanced TGFβ signalling and autophagy drive erythroid priming of hematopoietic stem cells in β-thalassemiaNature communications · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE263306_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1096683 and SRA study SRP499953. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 20 samples.
How we read this: 10 replicated groups read from 20 sample titles; they account for 20 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8189398 TAL_HSC_1 TAL_HSC
- GSM8189399 TAL_HSC_2 TAL_HSC
- GSM8189400 TAL_MPP_1 TAL_MPP
- GSM8189401 TAL_MPP_2 TAL_MPP
- GSM8189402 TAL_MEP_1 TAL_MEP
- GSM8189403 TAL_MEP_2 TAL_MEP
- GSM8189404 TAL_CMP_1 TAL_CMP
- GSM8189405 TAL_CMP_2 TAL_CMP
- GSM8189406 TAL_GMP_1 TAL_GMP
- GSM8189407 TAL_GMP_2 TAL_GMP
- GSM8189408 ND_HSC_1 ND_HSC
- GSM8189409 ND_HSC_2 ND_HSC
- GSM8189410 ND_MPP_1 ND_MPP
- GSM8189411 ND_MPP_2 ND_MPP
- GSM8189412 ND_MEP_1 ND_MEP
- GSM8189413 ND_MEP_2 ND_MEP
- GSM8189414 ND_CMP_1 ND_CMP
- GSM8189415 ND_CMP_2 ND_CMP
- GSM8189416 ND_GMP_1 ND_GMP
- GSM8189417 ND_GMP_2 ND_GMP
- GSE328457 Pooled combinatorial screening identifies transcription factor sets that drive hematopoietic progenitor-like cell fate 39 samples shares hematopoietic, drive
- GSE262911 Interferons and epigenetic mechanisms in training, priming and tolerance of monocytes and hematopoietic progenitors [RNA-seq] 24 samples shares hematopoietic, priming
- GSE292751 Matrix Stiffness-Sensitive LDHA Drives Autophagy of Pancreatic Ductal Adenocarcinoma via Lactate-Induced FOXO3 Expression and Lactylation 6 samples shares autophagy, drive
- GSE243641 Molecular and phenotypic blueprint of the hematopoietic compartment reveals proliferation stress as a driver of age-associated human stem cell dysfunctions 31 samples shares hematopoietic, drive
- GSE300808 RUNX1-Induced DNA Demethylation Drives Hematopoietic Stem and Progenitor Cell Development 29 samples shares hematopoietic, drive
- GSE262912 Interferons and epigenetic mechanisms in training, priming and tolerance of monocytes and hematopoietic progenitors [ATAC-seq] 24 samples shares hematopoietic, priming
- GSE75478 Single-cell indexed RNA-Seq of human hematopoietic stem and progenitors 2414 samples shares hematopoietic
- GSE285943 A reference model for circulating hematopoietic stem cells with applications to diagnostics 299 samples shares hematopoietic
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.