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Differential accessibility landscapes in MLL-AF9-driven leukemia stem cells upon inhibiiton of purine metabolism

GSE263344 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 6 samples Submitted 2025/02/17 Platform GPL19057
Summary
Targeted metabolomics analysis of bulk leukemia cells and leukemia stem cells (LSCs) derived from the MLL-AF9-driven acute myeloid leukemia (AML) model, and normal granulocyte-monocyte progenitor (GMP) cells and whole bone marrow (WBM) cells from healthy mice, revealed an enhanced purine metabolism in AML LSCs. Inhibiting the purine biosynthetic pathway using mycophenolate mofetil (MMF) promoted myeloid differentiation and induced alterations in the chromatin accessibility landscape. These findings underscore the pivotal role of purine metabolism in regulating LSC activity.
Published in
Guanine nucleotide biosynthesis blockade impairs MLL complex formation and sensitizes leukemias to menin inhibition
Shi X, Li M, Liu Z et al. · Nature communications 2025 · PMID 40102405 · doi:10.1038/s41467-025-57544-9
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Also filed as BioProject PRJNA1096740 and SRA study SRP500016. Searching any of these in the dataset finder brings you back here.

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