Gene expression in Pan02 tumors from mice that were either untreated, treated with a TGFb vaccine, with an anti-IL-6R blocking antibody or the combination of the TGFb vaccine and an anti-IL-6R blocking antibody
RNA-seq (gene expression) · mouse · 13 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 13 samples: 13 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- The antitumor activity of TGFβ-specific T cells is dependent on IL-6 signalingCellular & molecular immunology · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE263363_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1096817 and SRA study SRP500002. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 13 sample titles: 13 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8190250 Tumor_1, IL6R_block
- GSM8190251 Tumor_2, IL6R_block
- GSM8190252 Tumor_5, IL6R_block
- GSM8190253 Tumor_33, IL6R_block
- GSM8190254 Tumor_11, Untreated
- GSM8190255 Tumor_12, Untreated
- GSM8190256 Tumor_14, Untreated
- GSM8190257 Tumor_17, TGFb_vacc_IL6R_block
- GSM8190258 Tumor_18, TGFb_vacc_IL6R_block
- GSM8190259 Tumor_24, TGFb_vacc_IL6R_block
- GSM8190260 Tumor_22, TGFb_vacc
- GSM8190261 Tumor_25, TGFb_vacc
- GSM8190262 Tumor_36, TGFb_vacc
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- GSE161561 Transcriptome alteration in wild-type developing oligodendrocytes treated with interferon gamma and thapsigargin in comparison with untreated wild-type developing oligodendrocytes 40 samples shares untreated, treated
- GSE235291 Combination therapy with oncolytic virus and adoptively transferred T cells or mRNA vaccine amplifies antitumor effects 24 samples shares combination, vaccine
- GSE269051 Comparison of untreated and vancomycin-treated macrophages, with or without Candida albicans infection 24 samples shares untreated, treated
- GSE268240 Gene expression profiling of neutrophils isolated from bone marrow, spleen and tumor of H16sc-IS1-tumor-bearing mice treated with anti-IL1RAP or untreated. 24 samples shares untreated, treated
- GSE236765 RNA sequencing of LT-HSCs in the bone marrow from WT and Trim47-/- mice untreated or treated with 5-FU for 10 days 12 samples shares untreated, treated
- GSE235289 Combination therapy with oncolytic virus and adoptively transferred T cells or mRNA vaccine amplifies antitumor effects [RNA-Seq] 12 samples shares combination, vaccine
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.