GEO series
Single nuclei gene expression profile of brain cells from Pdgfbret/ret and Pdgfbret/wt mice
GSE263392
Mus musculus
Expression profiling by high throughput sequencing
24 samples
2024/10/14
GPL24247
Summary
Brain calcification, the ectopic mineral deposits of calcium phosphate, is a common radiological finding in elderly and in various neurodegenerative disorders and a diagnostic criterion for primary familial brain calcification (PFBC). We made use of single nuclei RNA sequencing to understand the effect of calcification pathology in the Pdgfb (ret/ret) model of PFBC. Calcifications are located in deep brain regions - hypothalamus, thalamus, mid brain, pons of Pdgfb (ret/ret) mice and absent in control Pdgfb (ret/wt) mice. Forebrain cortex and hippocampus regions in both genotypes are calcification free. Detailed descriptions of the mouse model can be found in the following publications:
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Paper (PMID 39467636) ↗
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