Sparing effects of FLASH irradiation in patient-derived lung tissue
RNA-seq (gene expression) · human · 27 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 27 samples: 9 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Sparing effects of FLASH irradiation in patient-derived lung tissueRadiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE263484_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1097629 and SRA study SRP500322. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 27 samples.
How we read this: 9 replicated groups read from 27 sample titles; they account for 27 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8193395 P17_NI_1 P17_NI
- GSM8193396 P17_NI_2 P17_NI
- GSM8193397 P17_NI_3 P17_NI
- GSM8193398 P17_IR_FLASH_9Gy_1 P17_IR_FLASH_9Gy
- GSM8193399 P17_IR_FLASH_9Gy_2 P17_IR_FLASH_9Gy
- GSM8193400 P17_IR_FLASH_9Gy_3 P17_IR_FLASH_9Gy
- GSM8193401 P17_IR_CONV_9Gy_1 P17_IR_CONV_9Gy
- GSM8193402 P17_IR_CONV_9Gy_2 P17_IR_CONV_9Gy
- GSM8193403 P17_IR_CONV_9Gy_3 P17_IR_CONV_9Gy
- GSM8193404 P18_NI_1 P18_NI
- GSM8193405 P18_NI_2 P18_NI
- GSM8193406 P18_NI_3 P18_NI
- GSM8193407 P18_IR_FLASH_9Gy_1 P18_IR_FLASH_9Gy
- GSM8193408 P18_IR_FLASH_9Gy_2 P18_IR_FLASH_9Gy
- GSM8193409 P18_IR_FLASH_9Gy_3 P18_IR_FLASH_9Gy
- GSM8193410 P18_IR_CONV_9Gy_1 P18_IR_CONV_9Gy
- GSM8193411 P18_IR_CONV_9Gy_2 P18_IR_CONV_9Gy
- GSM8193412 P18_IR_CONV_9Gy_3 P18_IR_CONV_9Gy
- GSM8193413 P19_NI_1 P19_NI
- GSM8193414 P19_NI_2 P19_NI
- GSM8193415 P19_NI_3 P19_NI
- GSM8193416 P19_IR_FLASH_9Gy_1 P19_IR_FLASH_9Gy
- GSM8193417 P19_IR_FLASH_9Gy_2 P19_IR_FLASH_9Gy
- GSM8193418 P19_IR_FLASH_9Gy_3 P19_IR_FLASH_9Gy
- GSM8193419 P19_IR_CONV_9Gy_1 P19_IR_CONV_9Gy
- GSM8193420 P19_IR_CONV_9Gy_2 P19_IR_CONV_9Gy
- GSM8193421 P19_IR_CONV_9Gy_3 P19_IR_CONV_9Gy
- GSE276387 Modeling Lung Adenocarcinoma Metastases Using Patient-Derived Organoids 26 samples shares patient-derived, lung
- GSE287078 Time- and Dose-Dependent Effects of Irradiation on Endothelial and Tumor Endothelial Cells: Transcriptional, Molecular, and Functional Changes Driving Activation In Vitro and In Vivo 30 samples shares irradiation
- GSE324866 1.Effects of L013 treatment on gene expression in KYSE150 and KYSE510 cells. 2. 5 Patient-derived organoids RNA-seq data 27 samples shares patient-derived
- GSE307568 Patient-derived organoid – immune cell co-culture platform for therapeutics discovery in high-grade endometrial cancer 189 samples shares patient-derived
- GSE311262 Recapitulating Patient-to-Patient Colorectal Cancer Tumor Heterogeneity Using Patient-Derived Xenograft Cells in an Engineered Tissue Model 18 samples shares patient-derived
- GSE308422 Human Blood Exposure to Neutron Radiation at Two Irradiation Facilities 120 samples shares irradiation
- GSE317901 Unraveling cetuximab response in head and neck cancer with APHRODYTHE, a multi-omics patient-derived xenograft platform 114 samples shares patient-derived
- GSE334033 A Patient-Derived Xenograft Model Identifies AK1 as a Key Regulator of Metastatic Potential in Primary Triple-Negative Breast Cancer 105 samples shares patient-derived
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.