GEO series
Sparing effects of FLASH irradiation in patient-derived lung tissue
GSE263484
Homo sapiens
Expression profiling by high throughput sequencing
27 samples
2025/09/08
GPL24676
Summary
This study aims to assess the effect of conventional radiotherapy compared to FLASH radiotherapy on healthy human lung tissue. FLASH radiotherapy, characterized by ultra-high dose rates, is hypothesized to spare healthy tissue from radiation-induced damage while maintaining efficacy against tumors. To achieve this goal and better characterize this sparing effect, bulk RNA sequencing analysis was conducted on 3 patients to study the molecular and cellular responses of lung tissue to both types of radiotherapy. The main objectives are to evaluate if FLASH radiotherapy effectively spares healthy lung tissue from radiation-induced damage and to understand the underlying molecular mechanisms behind this potential protective effect.
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Paper (PMID 40921334) ↗
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