Patient-derived organoid – immune cell co-culture platform for therapeutics discovery in high-grade endometrial cancer
RNA-seq (gene expression) · human · 189 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Topic
- Endometrial cancerThis series is part of our curated briefing on it.
- Samples
- 189 samples: 135 distinct titles, 30 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Ancestrally Diverse Autologous Patient-Derived Organoid-Immune Cell Coculture Platform for Addressing Immunotherapeutic Outcome Disparities in High-Grade Endometrial CancerCancer research communications · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE307568_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1322299 and SRA study SRP618670. Searching any of these in the dataset finder brings you back here.
Supports a case/control comparison: 98 samples read as cases, 91 as controls.
How we read this: Read from 189 sample titles: 135 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9226793 Patient-derived Organoid pid1 replicate1
- GSM9226794 Patient-derived Organoid pid2 replicate1
- GSM9226795 Organoid from matched normal or biopsy pid3 replicate1
- GSM9226796 Organoid from matched normal or biopsy pid3 replicate2
- GSM9226797 Organoid from matched normal or biopsy pid3 replicate3
- GSM9226798 Patient-derived Organoid pid3 replicate1
- GSM9226799 Patient-derived Organoid pid3 replicate2
- GSM9226800 Patient-derived Organoid pid4 replicate1
- GSM9226801 Patient-derived Organoid pid4 replicate2
- GSM9226802 Organoid from matched normal or biopsy pid5 replicate1
- GSM9226803 Organoid from matched normal or biopsy pid5 replicate2
- GSM9226804 Organoid from matched normal or biopsy pid5 replicate3
- GSM9226805 Organoid from matched normal or biopsy pid6 replicate1
- GSM9226806 Organoid from matched normal or biopsy pid6 replicate2
- GSM9226807 Organoid from matched normal or biopsy pid6 replicate3
- GSM9226808 Organoid from matched normal or biopsy pid6 replicate4
- GSM9226809 Patient-derived Organoid pid7 replicate1
- GSM9226810 Patient-derived Organoid pid8 replicate1
- GSM9226811 Patient-derived Organoid pid9 replicate1
- GSM9226812 Patient-derived Organoid pid9 replicate2
- GSM9226813 Patient-derived Organoid pid9 replicate3
- GSM9226814 Patient-derived Organoid pid9 replicate4
- GSM9226815 Patient-derived Organoid pid9 replicate5
- GSM9226816 Patient-derived Organoid pid9 replicate6
- GSM9226817 Patient-derived Organoid pid10 replicate1
- GSM9226818 Patient-derived Organoid pid10 replicate2
- GSM9226819 Patient-derived Organoid pid10 replicate3
- GSM9226820 Patient-derived Organoid pid10 replicate4
- GSM9226821 Patient-derived Organoid pid10 replicate5
- GSM9226822 Patient-derived Organoid pid10 replicate6
- GSM9226823 Organoid from matched normal or biopsy pid11 replicate1
- GSM9226824 Organoid from matched normal or biopsy pid11 replicate2
- GSM9226825 Organoid from matched normal or biopsy pid11 replicate3
- GSM9226826 Organoid from matched normal or biopsy pid11 replicate4
- GSM9226827 Patient-derived Organoid pid12 replicate1
- GSM9226828 Organoid from matched normal or biopsy pid13 replicate1
- GSM9226829 Patient-derived Organoid pid14 replicate1
- GSM9226830 Organoid from matched normal or biopsy pid14 replicate1
- GSM9226831 Organoid from matched normal or biopsy pid14 replicate2
- GSM9226832 Organoid from matched normal or biopsy pid14 replicate3
+ 149 more — browse all 189 samples with per-sample file links →
- GSE212217 Distinct Mechanisms of Mismatch-Repair Deficiency Delineate Two Modes of Response to Anti–PD-1 Immunotherapy in Endometrial Carcinoma 104 samples same disease briefing · shares endometrial
- GSE323965 Transcriptional signatures indicating RB function may predict response to CDK4/6 inhibition in endometrial cancer [RNA-Seq] 39 samples same disease briefing · shares endometrial
- GSE303681 Pre-receptor regulation of 11-oxyandrogens differs between normal and cancerous endometrium and across endometrial cancer grades and molecular subtypes 18 samples same disease briefing · shares endometrial
- GSE271198 RNA-seq analysis for endometrium and serous classification of endometrial cancer 16 samples same disease briefing · shares endometrial
- GSE306395 A very low carbohydrate, ketogenic diet suppresses tumor insulin signaling and enhances immune infiltration in women with endometrial cancer: results from a randomized feasibility study. 16 samples same disease briefing · shares endometrial
- GSE334100 Identification of genomic features that uniquely impact estrogen receptor alpha binding and its effects on gene expression in endometrial cancer [RNA-seq] 16 samples same disease briefing · shares endometrial
- GSE278879 Single nucleus RNA sequencing analysis reveals transcriptional heterogeneity of endometrioid endometrial cancer 11 samples same disease briefing · shares endometrial
- GSE275015 Clinical significance of p53 abnormal expression in low-grade endometrial cancer 9 samples same disease briefing · shares endometrial
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.