GEO series
Patient-derived organoid – immune cell co-culture platform for therapeutics discovery in high-grade endometrial cancer
GSE307568
Homo sapiens
Expression profiling by high throughput sequencing
189 samples
2026/02/14
GPL16791
Summary
We established a biobank of 85 patient-derived organoids (PDOs) generated from 44 individuals, encompassing a broad range of endometrial cancer (EC) subtypes, including a majority of high-grade endometrial cancer (HGEC) PDOs from African American patients. From these same patients, we isolated autologous immune cells, enabling the creation of PDO–immune cell co-cultures that reflect each patient’s unique characteristics without evoking allogeneic immune responses. To dissect the roles of antigen presentation pathways and evaluate proof-of-principle immunotherapeutic interventions, we performed bulk RNA sequencing, flow cytometry, and live-cell imaging.
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Paper (PMID 41709679) ↗
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