Astrocyte nuclear transcriptome from mouse cortex in Fmr1 KO and Smad4 conditional KO
RNA-seq (gene expression) · mouse · 19 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 19 samples: 6 × WT;Smad4cKO vs 5 × FXS vs 4 × WT vs 4 × FXS;Smad4cKOGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Suppression of astrocyte BMP signaling improves molecular signatures and functional deficits in a fragile X syndrome mouse modelNature communications · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE263517_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1097856 and SRA study SRP500481. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 19 samples.
How we read this: 4 replicated groups read from 19 sample titles; they account for 19 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8193896 WT1 WT
- GSM8193897 WT2 WT
- GSM8193898 WT3 WT
- GSM8193899 WT4 WT
- GSM8193900 WT;Smad4cKO1 WT;Smad4cKO
- GSM8193901 WT;Smad4cKO2 WT;Smad4cKO
- GSM8193902 WT;Smad4cKO3 WT;Smad4cKO
- GSM8193903 WT;Smad4cKO4 WT;Smad4cKO
- GSM8193904 WT;Smad4cKO5 WT;Smad4cKO
- GSM8193905 WT;Smad4cKO6 WT;Smad4cKO
- GSM8193906 FXS1 FXS
- GSM8193907 FXS2 FXS
- GSM8193908 FXS3 FXS
- GSM8193909 FXS4 FXS
- GSM8193910 FXS5 FXS
- GSM8193911 FXS;Smad4cKO1 FXS;Smad4cKO
- GSM8193912 FXS;Smad4cKO2 FXS;Smad4cKO
- GSM8193913 FXS;Smad4cKO3 FXS;Smad4cKO
- GSM8193914 FXS;Smad4cKO4 FXS;Smad4cKO
- GSE229815 Transcriptional profiling of 12 month striatum and cortex from a mouse model of Huntington's disease (Q140) crossed with Msh2 heterozygous or homozygous conditional knockout mice [Msh2_12mon] 138 samples shares conditional, cortex
- GSE229817 Transcriptional profiling of 6 month striatum and cortex from a mouse model of Huntington's disease (Q140) crossed with Msh2 conditional knockout mice [Msh2_6mon] 64 samples shares conditional, cortex
- GSE205029 Single Cell Sequencing Data of Mouse Spinal Cord with Dorsal Column Lesion and Astrocyte-Specific Ryk conditional Knockout 16 samples shares conditional, astrocyte
- GSE290477 Dexmedetomidine Inhibits Fear Memory Consolidation via the Astrocyte-Specific Srebf1-Phgdh Pathway in the Prelimbic Prefrontal Cortex 12 samples shares astrocyte, cortex
- GSE263080 RNA-sea of Smad4 wild-type or Smad4 knockout KPC PDAC organoids from monocultures or co-cultures with pancreatic stellate cells and RNA-seq of flow-sorted PSCs from the same co-cultures. 44 samples shares smad4
- GSE263081 RNA-sea of Smad4 wild-type or Smad4 knockout KvPC PDAC organoids from monocultures or co-cultures with pancreatic stellate cells and RNA-seq of flow-sorted PSCs from the same co-cultures. 35 samples shares smad4
- GSE338265 Smad4 and Eomes converge on a shared transcriptional program associated with inflammatory CD8 T-cell differentiation 31 samples shares smad4
- GSE262879 Single-cell RNA-sequencing of murine pancreatic tumors derived from the orthotopic transplantation of Smad4 wild-type (WT) or Smad4 knockout (KO) pancreatic ductal adenocarcinoma (PDAC) KPC organoids in nu/nu mice. 18 samples shares smad4
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.