Single-cell RNA-sequencing of murine pancreatic tumors derived from the orthotopic transplantation of Smad4 wild-type (WT) or Smad4 knockout (KO) pancreatic ductal adenocarcinoma (PDAC) KPC organoids in nu/nu mice.
Single-cell RNA-seq · mouse · 18 samples
- What it is
- Single-cell RNA-seqGene activity measured in thousands of individual cells, so cell types can be told apart.
- Organism
- Mus musculus (mouse)
- Samples
- 18 samples: 9 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- SMAD4 and KRAS Status Shapes Cancer Cell-Stromal Cross-Talk and Therapeutic Response in Pancreatic CancerCancer research · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE262879_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA1094572 and SRA study SRP498883. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 18 samples.
How we read this: 9 replicated groups read from 18 sample titles; they account for 18 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8180965 KPC_SMAD4_WT_SITTA11_SLX_21116 KPC_SMAD4_WT_SITTA11_SLX
- GSM8180966 KPC_SMAD4_WT_SITTE11_SLX_21116 KPC_SMAD4_WT_SITTE11_SLX
- GSM8180967 KPC_SMAD4_WT_SITTF11_SLX_21116 KPC_SMAD4_WT_SITTF11_SLX
- GSM8180968 KPC_SMAD4_KO_SITTA6_SLX_21116 KPC_SMAD4_KO_SITTA6_SLX
- GSM8180969 KPC_SMAD4_KO_SITTB11_SLX_21116 KPC_SMAD4_KO_SITTB11_SLX
- GSM8180970 KPC_SMAD4_KO_SITTB6_SLX_21116 KPC_SMAD4_KO_SITTB6_SLX
- GSM8180971 KPC_SMAD4_KO_SITTC11_SLX_21116 KPC_SMAD4_KO_SITTC11_SLX
- GSM8180972 KPC_SMAD4_KO_SITTD11_SLX_21116 KPC_SMAD4_KO_SITTD11_SLX
- GSM8180973 KPC_SMAD4_KO_SITTG11_SLX_21116 KPC_SMAD4_KO_SITTG11_SLX
- GSM8180990 KPC_SMAD4_WT_SITTA11_SLX_21289 KPC_SMAD4_WT_SITTA11_SLX
- GSM8180991 KPC_SMAD4_WT_SITTE11_SLX_21289 KPC_SMAD4_WT_SITTE11_SLX
- GSM8180992 KPC_SMAD4_WT_SITTF11_SLX_21289 KPC_SMAD4_WT_SITTF11_SLX
- GSM8180993 KPC_SMAD4_KO_SITTA6_SLX_21289 KPC_SMAD4_KO_SITTA6_SLX
- GSM8180994 KPC_SMAD4_KO_SITTB11_SLX_21289 KPC_SMAD4_KO_SITTB11_SLX
- GSM8180995 KPC_SMAD4_KO_SITTB6_SLX_21289 KPC_SMAD4_KO_SITTB6_SLX
- GSM8180996 KPC_SMAD4_KO_SITTC11_SLX_21289 KPC_SMAD4_KO_SITTC11_SLX
- GSM8180997 KPC_SMAD4_KO_SITTD11_SLX_21289 KPC_SMAD4_KO_SITTD11_SLX
- GSM8180998 KPC_SMAD4_KO_SITTG11_SLX_21289 KPC_SMAD4_KO_SITTG11_SLX
- GSE329665 Single-nuclei RNA-sequencing (snRNA-seq) of murine pancreatic tumors derived from the orthotopic transplantation of Smad4 WT or Smad4 KO pancreatic ductal adenocarcinoma (PDAC) KPC (i.e. KrasG12D; p53 mutant) organoids in C57BL/6J mice. 6 samples shares smad4, pdac, kpc, transplantation, rna-sequencing, adenocarcinoma, pancreatic
- GSE262878 Single-cell RNA-sequencing of murine pancreatic tumors derived from the orthotopic transplantation of Smad4 wild-type (WT) or Smad4 knockout (KO) pancreatic ductal adenocarcinoma (PDAC) KvPC organoids in nu/nu mice 8 samples shares smad4, pdac, transplantation, rna-sequencing, adenocarcinoma, single-cell, pancreatic
- GSE263080 RNA-sea of Smad4 wild-type or Smad4 knockout KPC PDAC organoids from monocultures or co-cultures with pancreatic stellate cells and RNA-seq of flow-sorted PSCs from the same co-cultures. 44 samples shares smad4, pdac, kpc, pancreatic
- GSE271510 Single-Cell RNA-Sequencing of Murine KPC Pancreatic Tumors 4 samples shares kpc, rna-sequencing, single-cell, pancreatic
- GSE263081 RNA-sea of Smad4 wild-type or Smad4 knockout KvPC PDAC organoids from monocultures or co-cultures with pancreatic stellate cells and RNA-seq of flow-sorted PSCs from the same co-cultures. 35 samples shares smad4, pdac, pancreatic
- GSE331086 The CD49b (ITGA2) Collagen Receptor Excludes CD8+ T Cell Infiltration in Pancreatic Ductal Adenocarcinoma (PDAC) 9 samples shares pdac, adenocarcinoma, pancreatic
- GSE311531 Analysis of murine pancreatitis tissues and KPC PDAC tumours 13 samples shares pdac, kpc
- GSE274516 Combination of MEK and Autophagy Inhibition in the preclinical GEMM model of PDAC (KPC mice) 6 samples shares pdac, kpc
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.