m6A sequencing of vitreous bodies of diabetic retinopathy patients
RNA-seq (gene expression) · human · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 12 samples: 3 × Input D vs 3 × Input NC vs 3 × IP D vs 3 × IP NCGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- FTO-modulated m(6)A demethylation and upregulation of KIF11 mRNA promotes retinal microvascular dysfunction in diabetic retinopathyJournal of translational medicine · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE263660_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1098720 and SRA study SRP500820. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8196115 Input DR_1 Input D
- GSM8196116 Input DR_2 Input D
- GSM8196117 Input DR_3 Input D
- GSM8196118 Input NC_1 Input NC
- GSM8196119 Input NC_2 Input NC
- GSM8196120 Input NC_3 Input NC
- GSM8196121 IP DR_1 IP D
- GSM8196122 IP DR_2 IP D
- GSM8196123 IP DR_3 IP D
- GSM8196124 IP NC_1 IP NC
- GSM8196125 IP NC_2 IP NC
- GSM8196126 IP NC_3 IP NC
- GSE276892 The Multifaceted Role of Vitreous Hyalocytes: Orchestrating Inflammation, Angiomodulation, and Erythrophagocytosis in Proliferative Diabetic Retinopathy 10 samples shares retinopathy, vitreous, diabetic
- GSE299876 N-acetyl-L-cysteine ethyl ester (NACET) induces the transcription factor NRF2 in the retina and prevents its aging and diabetic retinopathy. [II] 18 samples shares retinopathy, diabetic
- GSE307925 Proliferative diabetic retinopathy subtypes defined by immune defense and endothelial mitochondrial dysfunction 12 samples shares retinopathy, diabetic
- GSE304690 PDZK1 Protects Against RPE Senescence by Targeting the 14-3-3ε-mTOR Axis to Attenuate Early Diabetic Retinopathy [MG_HG] 10 samples shares retinopathy, diabetic
- GSE301191 The role of transcription factors PES1 in Diabetic Retinopathy 8 samples shares retinopathy, diabetic
- GSE290024 Unveiling the Cellular and Molecular Mechanisms of Diabetic Retinopathy with Human Retinal Organoids 6 samples shares retinopathy, diabetic
- GSE297740 B cell imprinting in children impairs antibodies to the hemagglutinin stalk 68 samples shares bodies
- GSE322576 Inflammatory arthritis immune related adverse events represent a unique autoimmune disease entity primarily driven by T cells, but likely not autoantibodies 38 samples shares bodies
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.