Regulation of NK cell development, maturation, and antitumor responses by the nuclear receptor NR2F6
RNA-seq (gene expression) · mouse · 14 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 14 samples: 4 × NK_IL15C_WT vs 4 × NK_IL15C_N vs 3 × NK_UN_WT vs 3 × NK_UN_NGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Regulation of NK cell development, maturation, and antitumor responses by the nuclear receptor NR2F6Cell death & disease · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE263734_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1099132 and SRA study SRP501142. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 14 samples.
How we read this: 4 replicated groups read from 14 sample titles; they account for 14 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8197566 NK_UN_WT3 NK_UN_WT
- GSM8197567 NK_UN_WT4 NK_UN_WT
- GSM8197568 NK_UN_WT5 NK_UN_WT
- GSM8197569 NK_UN_N7 NK_UN_N
- GSM8197570 NK_UN_N8 NK_UN_N
- GSM8197571 NK_UN_N10 NK_UN_N
- GSM8197572 NK_IL15C_WT1 NK_IL15C_WT
- GSM8197573 NK_IL15C_WT2 NK_IL15C_WT
- GSM8197574 NK_IL15C_WT3 NK_IL15C_WT
- GSM8197575 NK_IL15C_WT4 NK_IL15C_WT
- GSM8197576 NK_IL15C_N6 NK_IL15C_N
- GSM8197577 NK_IL15C_N7 NK_IL15C_N
- GSM8197578 NK_IL15C_N8 NK_IL15C_N
- GSM8197579 NK_IL15C_N9 NK_IL15C_N
- GSE317634 Negative regulation of TH17-mediated inflammation by the nuclear receptor REV-ERBβ 26 samples shares receptor, nuclear
- GSE301140 Dual Programmed Death Receptor-1 and Vascular Endothelial Growth Factor Receptor-2 Blockade Promotes Vascular Normalization and Enhances Antitumor Immune Responses in Hepatocellular Carcinoma 18 samples shares antitumor, receptor
- GSE325918 Nuclear receptor Nur77 resolves the inflammatory response of macrophages primarily by regulating expression of AP-1 transcription factors and their target genes [RNA-seq] 32 samples shares receptor, nuclear
- GSE294805 Effect of cardiomyocyte-specific activation of nuclear receptor subfamily 4 group A member 2 (NR4A2) on poly(A) RNA expression profile in the mouse heart [RNA-seq] 32 samples shares receptor, nuclear
- GSE272424 Rejuvenating endogenous antitumor immunity via a chimeric receptor-engineered oncolytic virus targeting tumor-associated macrophages 6 samples shares antitumor, receptor
- GSE267452 Loss of Nuclear Receptor Nr4a3 Alleviates Cellular Senescence to Promote Adult Direct Cardiac Reprogramming 54 samples shares receptor, nuclear
- GSE326173 Nuclear receptor Nur77 resolves the inflammatory response of macrophages primarily by regulating expression of AP-1 transcription factors and their target genes [ChIP-seq] 42 samples shares receptor, nuclear
- GSE234065 Unexpected nuclear hormone receptor and chromatin dynamics regulate estrous cycle dependent gene expression 32 samples shares receptor, nuclear
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.