GEO series
Deciphering lineage decision of hematopoietic stem cells at homeostasis and aging
GSE263781
Mus musculus
Expression profiling by high throughput sequencing; Other
15 samples
2026/03/24
GPL24247
Summary
To revealed the mechanism of long-term hematopoietic stem cells (LT-HSCs) lineage decision and bias during aging, we applied scRNA sequencing with three sub-clusters within the compartment in different age groups, namely CD150hiSca1hi LT-HSCs, CD150hiSca1lo LT-HSCs and CD150lo LT-HSCs. These three LT-HSC subsets encompass a spectrum of lineage specification and commitment cell states, which were further segregated into 6 different clusters. Characterization of the self-renewal capacity and lineage potential of the quiescence HSC subpopulation by transplantation assays revealed the identity of bona fide HSC (Meg3+-HSC), which expanded dramatically started at middle-age, with dynamic transcriptional activities associated with protein modification and platelets activation.
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Paper (PMID 42191895) ↗
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