GEO series
Genetic disruption of class I HLA in cutaneous T-cell lymphoma
GSE263881
Homo sapiens
Expression profiling by high throughput sequencing; Other
18 samples
2025/02/05
GPL34284GPL24676GPL20795
Summary
Genetic disruption of class I HLA is a common mechanism of immune evasion and immunotherapy resistance in many other cancers but has not yet been characterized in cutaneous T-cell lymphoma (CTCL). We performed single-cell RNA sequencing (scRNA-seq) on tumor samples from patients with CTCL to demonstrate the tumor-specificity and intratumoral heterogeneity of such abnormalities.
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Paper (PMID 39388712) ↗
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