Effect of CSF1R targeting on human macrophages in normoxia and hypoxia
RNA-seq (gene expression) · human · 16 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 16 samples: 16 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Metabolic reprogramming of hypoxic tumor-associated macrophages through CSF-1R targeting favors treatment efficiency in colorectal cancersJournal for immunotherapy of cancer · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE263919_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1099919 and SRA study SRP501624. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 16 sample titles: 16 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8207483 Macrophages, 1 Normoxia Vehicle
- GSM8207484 Macrophages, 1 Normoxia Edicotinib
- GSM8207485 Macrophages, 1 Hypoxia Vehicle
- GSM8207486 Macrophages, 1 Hypoxia Edicotinib
- GSM8207487 Macrophages, 2 Normoxia Vehicle
- GSM8207488 Macrophages, 2 Normoxia Edicotinib
- GSM8207489 Macrophages, 2 Hypoxia Vehicle
- GSM8207490 Macrophages, 2 Hypoxia Edicotinib
- GSM8207491 Macrophages, 3 Normoxia Vehicle
- GSM8207492 Macrophages, 3 Normoxia Edicotinib
- GSM8207493 Macrophages, 3 Hypoxia Vehicle
- GSM8207494 Macrophages, 3 Hypoxia Edicotinib
- GSM8207495 Macrophages, 7 Normoxia Vehicle
- GSM8207496 Macrophages, 7 Normoxia Edicotinib
- GSM8207497 Macrophages, 7 Hypoxia Vehicle
- GSM8207498 Macrophages, 7 Hypoxia Edicotinib
- GSE281471 Targeting CD206+ macrophages disrupts the establishment of a key anti-tumor immune axis [Bulk RNA-seq] 243 samples shares macrophages, targeting
- GSE334631 Transcriptional response of A549 lung cancer cells to X-rays under normoxia, or chronic or transient hypoxia 24 samples shares normoxia, hypoxia
- GSE334632 Transcriptional response of A549 lung cancer cells to carbon ions under normoxia, or chronic or transient hypoxia 24 samples shares normoxia, hypoxia
- GSE314728 KG1a phenotypic subsets under normoxia and hypoxia 12 samples shares normoxia, hypoxia
- GSE224392 Immunotherapies that repolarize macrophages and regulatory T cells enhance the effect of chemotherapy in high-grade serous ovarian cancer (Human) 21 samples shares macrophages
- GSE222556 Neoadjuvant PARPi or Chemotherapy in Ovarian Cancer Informs Targeting Effector Treg Cells for Homologous-Recombination-Deficient Tumors [10x scRNA-seq] 67 samples shares targeting
- GSE272396 Endogenously produced itaconate negatively regulates innate-driven cytokine production and drives global ubiquitination in human macrophages 36 samples shares macrophages
- GSE311629 Biomimetic model of human small airways reveals functional impacts of the cystic fibrosis microenvironment on monocytes and macrophages 35 samples shares macrophages
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.