The SUMOylation inhibitor TAK-981 induces a transcriptional reprogramming in human Natural Killer cells
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 19 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 19 samples: 17 distinct titles, 2 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Targeting SUMOylation Triggers IFN-β-dependent Activation of Patient and Allogenic NK Cells in Preclinical Models of Acute Myeloid LeukemiaMolecular cancer therapeutics · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE263924_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1100197 and SRA study SRP552751. Searching any of these in the dataset finder brings you back here.
How we read this: Read from 19 sample titles: 17 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8068093 NK_DMSO_rep1 (RNA-seq)
- GSM8068094 NK_TAK981_rep1 (RNA-seq)
- GSM8068095 NK_DMSO_rep2 (RNA-seq)
- GSM8068096 NK_TAK981_rep2 (RNA-seq)
- GSM8068097 NK_DMSO_rep3 (RNA-seq)
- GSM8068098 NK_TAK981_rep3 (RNA-seq)
- GSM8207517 NK_DMSO_rep1 (ATAC-seq)
- GSM8207518 NK_TAK981_rep1 (ATAC-seq)
- GSM8207519 NK_DMSO_rep2 (ATAC-seq)
- GSM8207520 NK_TAK981_rep2 (ATAC-seq)
- GSM8693901 NK_NT_rep3
- GSM8693902 NK_TAK981_rep3
- GSM8693903 NK_NT_rep4
- GSM8693904 NK_TAK981_rep4
- GSM8695924 HD67_NT_H3K27ac
- GSM8695925 HD67_TAK_H3K27ac
- GSM8695926 HD68_NT_H3K27ac
- GSM8695927 HD68_TAK_H3K27ac
- GSM8695928 HD68_NT_IgG
- GSE286057 Ovarian cancer metastasis to the human omentum disrupts organ homeostasis and induces fundamental tissue reprogramming 36 samples shares reprogramming, induces
- GSE307326 Continuous NRTI-based antiretroviral therapy induces progressive senescence-like reprogramming of alveolar macrophages [snMultiomics] 32 samples shares reprogramming, induces
- GSE282387 Temozolomide Induces Glioblastoma Dedifferentiation into Highly Malignant Stem-like Cells Through Senescence-Associated Reprogramming via HIF1α/HIF2α Regulation [RNA-seq] 12 samples shares reprogramming, induces
- GSE280564 Reprogramming of normal fibroblasts into ovarian cancer-associated fibroblasts via non-vesicular paracrine signaling induces an activated fibroblast phenotype 12 samples shares reprogramming, induces
- GSE278576 Epigenetic and 3D genome reprogramming during the aging of human hippocampus 80 samples shares reprogramming
- GSE283621 Single-cell multi-omics analysis identifies metabolism-linked epigenetic reprogramming as a driver of therapy-resistant medulloblastoma 79 samples shares reprogramming
- GSE325486 ESR1 mutations shape the clonal dynamics, genetic diversity and cellular states of acquired resistance to CDK4/6 inhibitors 57 samples shares inhibitor
- GSE254366 Epigenome reprogramming through H3K27 and H3K4 trimethylation as a resistance mechanism to DNA methylation inhibition in BRAFV600E-mutated CRC. 36 samples shares reprogramming
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.