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Human iPSC-derived cardiomyocyte from a patient with dilated phase of hypertrophic cardiomyopathy

GSE263980 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/04/06 Platform GPL18573
Summary
Hypertrophic cardiomyopathy (HCM) is an inherited cardiac disorder characterized by ventricular wall hypertrophy and diastolic dysfunction. Most patients with HCM are often a slowly progressive disease and may be asymptomatic; however, some progress to the dilated phase of HCM (D-HCM), and have a poorer prognosis. This study established disease-specific human induced pluripotent stem cells (iPSCs) from a patient with D-HCM harboring a truncating mutation in MYBPC3, and compared transcriptomes of iPSCs-derived cardiomyocytes between healthy control and D-HCM.
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Direct links to NCBI, no account and no request form: the whole study as GSE263980_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1096120 and SRA study SRP499665. Searching any of these in the dataset finder brings you back here.

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